Therapy Detail
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| Therapy Name | DV-10 + Idecabtagene Vicleucel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| DV-10 | DV10|DV 10 | DV-10 is a tumor-specific, replication competent adenovirus engineered to express IL18 and CXCL9, as well as secreted and membrane-bound forms of TNFRSF17 (BCMA), which potentially increases immune activation and infiltration into the tumor microenvironment (Journal for ImmunoTherapy of Cancer 2025;13, Suppl_2, 393). | ||
| Idecabtagene Vicleucel | Abecma | Ide-cel|bb2121|BMS-986395 | TNFRSF17 Immune Cell Therapy 28 | Abecma (idecabtagene vicleucel) is a chimeric antigen receptor T cell specific to B cell maturation antigen (BCMA), which could potentially result in decreased volume of BCMA expressing tumor cells (PMID: 32707894, PMID: 33626253). Abecma (idecabtagene vicleucel) is FDA approved for use in adult patients with relapsed or refractory multiple myeloma after four or more prior lines of therapy (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07544589 | Phase I | DV-10 + Idecabtagene Vicleucel | A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers | Recruiting | USA | 0 |
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