Therapy Detail
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| Therapy Name | BI 764532 + Zocilurtatug pelitecan |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BI 764532 | BI-764532|BI764532|Obrixtamig | CD3 Antibody 128 DLL3 Antibody 10 | BI 764532 is a bispecific antibody targeting DLL3 and CD3, which may lead to activation of T-cell-mediated immune response against DLL3-expressing tumor cells (J Clin Oncol 41, 2023 (suppl 16; abstr 8502)). | |
| Zocilurtatug pelitecan | ZL-1310|ZL1310|ZL 1310|YL212|YL 212|YL-212|ADC SC-002 | DLL3 Antibody 10 | Zocilurtatug pelitecan (ZL-1310) is an antibody-drug conjugate (ADC) comprising an antibody targeting DLL3 linked to a camptothecin derivative, which potentially inhibits tumor growth (ESMO Open, Volume 9, 102891). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07707895 | Phase Ib/II | Atezolizumab + BI 764532 + Zocilurtatug pelitecan BI 764532 + Zocilurtatug pelitecan | DAREON-36: A Study to Test Obrixtamig in Combination With ZL-1310 in People With Advanced Small Cell Lung Cancer or Other Neuroendocrine Cancers | Not yet recruiting | USA | POL | NLD | GBR | FRA | ESP | DEU | BEL | AUS | 2 |
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