Therapy Detail
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| Therapy Name | Carboplatin + Etoposide + PT217 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| Etoposide | Vepesid | EPEG|Eposin|VP-16|VP-16-213 | TOPO2 inhibitor 5 | Vepesid (etoposide) binds to and inhibits DNA topoisomerase II, resulting in accumulated DNA damage, inhibition of replication, and cell death (NCI Drug Dictionary). |
| PT217 | PT-217|PT 217 | CD47 Antibody 31 DLL3 Antibody 10 | PT217 is a bispecific antibody that targets DLL3 and CD47, potentially resulting in enhanced tumor cell phagocytosis and inhibition of tumor growth (Cancer Res (2022) 82 (12_Supplement): 2908). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05652686 | Phase Ib/II | PT217 Carboplatin + Etoposide + PT217 Lurbinectedin + PT217 Paclitaxel + PT217 PT217 + Topotecan Irinotecan + PT217 Atezolizumab + PT217 | A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study) | Recruiting | USA | 0 |
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