Therapy Detail
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| Therapy Name | Lurbinectedin + PT217 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Lurbinectedin | Zepzelca | PM01183 | Chemotherapy - Alkylating 18 | Zepzelca (lurbinectedin) is an alkaloid analogue that binds to the minor groove of DNA, resulting in delayed cell cycle progression and cell death (PMID: 20977459). Zepzelca (lurbinectedin) is an FDA-approved chemotherapy agent (FDA.gov). |
| PT217 | PT-217|PT 217 | CD47 Antibody 31 DLL3 Antibody 10 | PT217 is a bispecific antibody that targets DLL3 and CD47, potentially resulting in enhanced tumor cell phagocytosis and inhibition of tumor growth (Cancer Res (2022) 82 (12_Supplement): 2908). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05652686 | Phase Ib/II | PT217 Carboplatin + Etoposide + PT217 Lurbinectedin + PT217 Paclitaxel + PT217 PT217 + Topotecan Irinotecan + PT217 Atezolizumab + PT217 | A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study) | Recruiting | USA | 0 |
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