Therapy Detail
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| Therapy Name | ASP1002 + Docetaxel + Ramucirumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ASP1002 | ASP-1002|ASP 1002 | ASP1002 is a bispecific antibody targeting CD137 and CLDN4, which potentially enhances antitumor immune response and inhibits tumor growth (Journal for ImmunoTherapy of Cancer 2024;12). | ||
| Docetaxel | Taxotere | RP56976 | Antimicrotubule Agent 14 | Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (PMID: 32496783, PMID: 32366558). |
| Ramucirumab | Cyramza | LY3009806 | VEGFR2 Antibody 5 | Cyramza (ramucirumab) is a monoclonal antibody, which binds and inhibits VEGFR2 (KDR) resulting in decreased angiogenesis (PMID: 24094768). Cyramza (ramucirumab) is FDA approved for use as a monotherapy or in combination with paclitaxel in patients with gastric or gastroesophageal junction adenocarcinoma who progressed on chemotherapy, in combination with erlotinib as first-line therapy in patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion mutations or L858R, in combination with decetaxel in patients with NSCLC who progressed on prior therapy, in combination with FOLFIRI in patients with colorectal cancer who progressed on prior therapy, and as monotherapy in patients with hepatocellular carcinoma who have received sorafenib (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05719558 | Phase I | ASP1002 + Bevacizumab ASP1002 + Pembrolizumab ASP1002 + Docetaxel + Ramucirumab ASP1002 + Carboplatin + Pembrolizumab + Pemetrexed Disodium ASP1002 ASP1002 + Bevacizumab + Trifluridine-tipiracil hydrochloride ASP1002 + Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin ASP1002 + Bevacizumab + Fluorouracil + Irinotecan + Leucovorin | A Study of ASP1002 in Adults for Treatment of Solid Tumors | Recruiting | USA | 0 |
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