Therapy Detail
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| Therapy Name | ASP1002 + Pembrolizumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ASP1002 | ASP-1002|ASP 1002 | ASP1002 is a bispecific antibody targeting CD137 and CLDN4, which potentially enhances antitumor immune response and inhibits tumor growth (Journal for ImmunoTherapy of Cancer 2024;12). | ||
| Pembrolizumab | Keytruda | MK-3475 | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 138 | Keytruda (pembrolizumab) is an antibody against PD-1 that activates T-cell mediated anti-tumor immune response (PMID: 25977344). Keytruda (pembrolizumab) is approved in melanoma, SCLC, HNSCC, classical Hodgkin Lymphoma, PMBL, urothelial carcinoma, HCC, Merkel cell carcinoma, NMIBC, cutaneous SCC, MSI-H or dMMR or TMB high advanced solid tumors, NSCLC and CD274 (PD-L1)-positive NSCLC, esophageal SCC, cervical cancer, HNSCC, and TNBC, in combination with platnum-based chemo in NSCLC, with pemetrexed and platinum in pleural mesothelioma and non-sNSCLC with no EGFR or ALK mutations, with carboplatin and paclitaxel/nab-paclitaxel in sNSCLC, with axitinib or lenvatinib in RCC, with lenvatinib in non-MSI-H or dMMR endometrial carcinoma, with platinum and fluoropyrimidine-based chemo for esophageal or gastroesophageal carcinoma, HER2-negative gastric or GEJ adenocarcinoma, with Herceptin (trastuzumab), fluoropyrimidine- and platinum-containing chemo for CD274 (PD-L1)-positive, HER2-positive gastric or GEJ adenocarcinoma, with platinum-based chemotherapy, with or without bevacizumab, for patients with CD274 (PD-L1)-positive cervical cancer, with gemcitabine and cisplatin for biliary tract cancer, with chemoradiation for cervical cancer, with carboplatin and paclitaxel for endometrial carcinoma, with paclitaxel with or without bevacizumab for epithelial ovarian, Fallopian tube, and peritonium cancer, with Padcev for MIBC (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05719558 | Phase I | ASP1002 + Bevacizumab ASP1002 + Pembrolizumab ASP1002 + Docetaxel + Ramucirumab ASP1002 + Carboplatin + Pembrolizumab + Pemetrexed Disodium ASP1002 ASP1002 + Bevacizumab + Trifluridine-tipiracil hydrochloride ASP1002 + Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin ASP1002 + Bevacizumab + Fluorouracil + Irinotecan + Leucovorin | A Study of ASP1002 in Adults for Treatment of Solid Tumors | Recruiting | USA | 0 |
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