Therapy Detail
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| Therapy Name | ASP1002 + Bevacizumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ASP1002 | ASP-1002|ASP 1002 | ASP1002 is a bispecific antibody targeting CD137 and CLDN4, which potentially enhances antitumor immune response and inhibits tumor growth (Journal for ImmunoTherapy of Cancer 2024;12). | ||
| Bevacizumab | Avastin | VEGF Antibody 17 VEGFR Inhibitor (Pan) 36 | Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05719558 | Phase I | ASP1002 + Bevacizumab ASP1002 + Pembrolizumab ASP1002 + Docetaxel + Ramucirumab ASP1002 + Carboplatin + Pembrolizumab + Pemetrexed Disodium ASP1002 ASP1002 + Bevacizumab + Trifluridine-tipiracil hydrochloride ASP1002 + Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin ASP1002 + Bevacizumab + Fluorouracil + Irinotecan + Leucovorin | A Study of ASP1002 in Adults for Treatment of Solid Tumors | Recruiting | USA | 0 |
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