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Therapy Detail
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| Therapy Name | Ascrinvacumab + Regorafenib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Ascrinvacumab | PF-03446962|GT90001|GT-90001|GT 90001 | Ascrinvacumab (PF-03446962) is a monoclonal antibody that binds and inhibits activin-like receptor kinase 1 (ALK-1), potentially resulting in decreased tumor angiogenesis and proliferation (PMID: 31444620). | ||
| Regorafenib | Stivarga | BAY 73-4506 | BRAF Inhibitor 25 CRAF Inhibitor 12 KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 RET Inhibitor 53 VEGFR Inhibitor (Pan) 36 VEGFR2 Inhibitor 37 | Stivarga (regorafenib) is an inhibitor of several kinases including VEGFR, RET, KIT, PDGFR and RAF, thereby inhibiting tumor angiogenesis and tumor cell proliferation (PMID: 24756792). Stivarga (regorafenib) is FDA approved for colorectal cancer, hepatocellular carcinoma, and GIST (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02116894 | Phase I | Ascrinvacumab + Regorafenib | Safety Study of Regorafenib With PF-03446962 to Treat Colorectal Cancer | Completed | USA | 0 |
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