Therapy Detail
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| Therapy Name | Daraxonrasib + Zoldonrasib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Daraxonrasib | Rasonque | RMC 6236|RMC6236|RMC-6236 | RAS Inhibitor (Pan) 16 | Rasonque (daraxonrasib) forms a binary complex with CypA, which prevents GTP-bound RAS from interacting with downstream effectors, potentially leading to anti-tumor activity (Cancer Res 2022;82(12_Suppl): Abstract nr 3597, PMID: 38593348). Rasonque (daraxonrasib) is FDA-approved for use in patients with metastatic pancreatic adenocarcinoma (FDA.gov). |
| Zoldonrasib | RMC 9805|RMC9805|RMC-9805|RM036|RM-036|RM 036 | KRAS G12D Inhibitor 26 | Zoldonrasib (RMC-9805) inhibits KRAS G12D, which potentially results in reduced downstream signaling and proliferation, induction of apoptosis, and decreased tumor growth (Cancer Res 2023;83(7_Suppl):Abstract nr 526). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07805954 | Phase III | Gemcitabine + Nab-paclitaxel Daraxonrasib + Zoldonrasib | Study of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) Versus Gemcitabine and Nab-Paclitaxel as First-Line Treatment in Metastatic KRAS G12D-Mutated Pancreatic Adenocarcinoma (RASolute 309) | Recruiting | USA | 0 |
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