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Therapy Name	Azacitidine + Gemcitabine + Vorinostat
Synonyms
Therapy Description

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Azacitidine	Vidaza	azacytidine\|CC-486\|5-azacytidine\|5-AC\|U-18496\|Onureg	DNMT inhibitor (Pan) 5	Vidaza (azacitidine) is a cytidine analog that incorporates into DNA and RNA and binds to DNA methyltransferases (DNMTs), resulting in DNMT degradation and decreased DNA methylation, and leading to increased tumor cell death (PMID: 28159832, PMID: 28067760). Vidaza (azacitidine) is FDA-approved for use in patients with some subtypes of myelodysplastic syndrome and Onureg (azacitidine) is FDA approved for use in continued treatment of acute myeloid leukemia(FDA.gov).
Gemcitabine	Gemzar	Difluorodeoxycytidine Hydrochlorothiazide\|LY-188011	Chemotherapy - Antimetabolite 14	Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary).
Vorinostat	Zolinza	SAHA\|L-001079038\|MSK390	HDAC Inhibitor 45	Zolinza (vorinostat) inhibits HDAC activity, resulting in cell-cycle arrest, decreased proliferation, and increased differentiation of tumor cells (PMID: 9501205, PMID: 11731433, PMID: 11016644). Zolinza (vorinostat) is FDA approved for use in cutaneous T-cell lymphoma (FDA.gov).

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Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Filtering

Case insensitive filtering will display rows if any text in any cell matches the filter term
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Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT01983969	Phase Ib/II	Rituximab Dexamethasone Busulfan + Melphalan Azacitidine + Gemcitabine + Vorinostat	Aza-SAHA-GBM With AutoSCT for Refractory Lymphoma	Completed	USA	0

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