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Drug Name Vorinostat
Trade Name Zolinza
Synonyms SAHA|L-001079038|MSK390
Drug Descriptions

Zolinza (vorinostat) inhibits HDAC activity, resulting in cell-cycle arrest, decreased proliferation, and increased differentiation of tumor cells (PMID: 9501205, PMID: 11731433, PMID: 11016644). Zolinza (vorinostat) is FDA approved for use in cutaneous T-cell lymphoma (FDA.gov).

DrugClasses HDAC Inhibitor 45
CAS Registry Number 149647-78-9
NCIT ID C1796

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Therapy Name Drugs Efficacy Evidence Clinical Trials
131I-MIBG + Dinutuximab + Sargramostim + Vorinostat 131I-MIBG Dinutuximab Sargramostim Vorinostat 0 1
131I-MIBG + Vorinostat 131I-MIBG Vorinostat 0 2
ABT-737 + Vorinostat ABT-737 Vorinostat 0 0
AGI-5198 + Vorinostat AGI-5198 Vorinostat 1 0
Alisertib + Vorinostat Alisertib Vorinostat 0 0
Alvespimycin + Vorinostat Alvespimycin Vorinostat 1 0
Azacitidine + Cytarabine + Filgrastim + Fludarabine + Venetoclax + Vorinostat Azacitidine Cytarabine Filgrastim Fludarabine Venetoclax Vorinostat 0 1
Azacitidine + Gemcitabine + Vorinostat Azacitidine Gemcitabine Vorinostat 0 1
Azacitidine + Vorinostat Azacitidine Vorinostat 0 1
Bevacizumab + Vorinostat Bevacizumab Vorinostat 0 1
Bortezomib + Sorafenib + Vorinostat Bortezomib Sorafenib Vorinostat 0 1
Bortezomib + Vorinostat Bortezomib Vorinostat 0 0
Busulfan + Clofarabine + Cyclophosphamide + Gemcitabine + Mycophenolate mofetil + Rituximab + Tacrolimus + Vorinostat Busulfan Clofarabine Cyclophosphamide Gemcitabine Mycophenolate mofetil Rituximab Tacrolimus Vorinostat 0 1
Busulfan + Clofarabine + Cyclophosphamide + Gemcitabine + Mycophenolate mofetil + Tacrolimus + Vorinostat Busulfan Clofarabine Cyclophosphamide Gemcitabine Mycophenolate mofetil Tacrolimus Vorinostat 0 1
Carboplatin + Paclitaxel + Vorinostat Carboplatin Paclitaxel Vorinostat 0 0
Carboplatin + Vorinostat Carboplatin Vorinostat 0 1
Cefixime + Irinotecan + Temozolomide + Vincristine Sulfate + Vorinostat Cefixime Irinotecan Temozolomide Vincristine Sulfate Vorinostat 0 1
Cisplatin + Vorinostat Cisplatin Vorinostat 0 1
Doxorubicin + Vorinostat Doxorubicin Vorinostat 0 0
Etoposide + Vorinostat Etoposide Vorinostat 0 1
Everolimus + Vorinostat Everolimus Vorinostat 0 0
Fenretinide + Vorinostat Fenretinide Vorinostat 1 0
Gemcitabine + Nab-paclitaxel + Sorafenib + Vorinostat Gemcitabine Nab-paclitaxel Sorafenib Vorinostat 0 1
Hydroxychloroquine + Vorinostat Hydroxychloroquine Vorinostat 0 2
Ixazomib + Vorinostat Ixazomib Vorinostat 0 1
Lapatinib + Vorinostat Lapatinib Vorinostat 0 1
Lenalidomide + Vorinostat Lenalidomide Vorinostat 0 1
Marizomib + Vorinostat Marizomib Vorinostat 0 0
Olaparib + Vorinostat Olaparib Vorinostat 0 1
Osimertinib + Vorinostat Osimertinib Vorinostat 0 0
P10 + Vorinostat P10 Vorinostat 0 0
Paclitaxel + Vorinostat Paclitaxel Vorinostat 0 2
Palbociclib + Vorinostat Palbociclib Vorinostat 0 0
Pazopanib + Vorinostat Pazopanib Vorinostat 4 0
Pembrolizumab + Tamoxifen + Vorinostat Pembrolizumab Tamoxifen Vorinostat 0 2
Pembrolizumab + Temozolomide + Vorinostat Pembrolizumab Temozolomide Vorinostat 0 1
Pembrolizumab + Vorinostat Pembrolizumab Vorinostat 0 4
Pictilisib + Vorinostat Pictilisib Vorinostat 1 0
PLX4720 + Vorinostat PLX4720 Vorinostat 1 0
Retroviral vector transduced B7-H3 CAR T cells + Vorinostat Retroviral vector transduced B7-H3 CAR T cells Vorinostat 0 0
Sirolimus + Vorinostat Sirolimus Vorinostat 0 0
Sorafenib + Vorinostat Sorafenib Vorinostat 0 1
Sulfopin + Vorinostat Sulfopin Vorinostat 0 0
Tanespimycin + Vorinostat Tanespimycin Vorinostat 1 0
Temsirolimus + Vorinostat Temsirolimus Vorinostat 0 1
Tozasertib + Vorinostat Tozasertib Vorinostat 0 0
Trametinib + Vorinostat Trametinib Vorinostat 1 0
Vorinostat Vorinostat 4 32
Vorinostat + WP1066 Vorinostat WP1066 0 0


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