Therapy Detail

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Dexamethasone	Adexone	Desametasone

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT04524455	Phase I	Dexamethasone AMG 404 + Blinatumomab	A Study of Blinatumomab in Combination With AMG 404 for the Treatment of Adults With Acute Lymphoblastic Leukemia (ALL)	Completed	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| AUT \| AUS	0
NCT01729091	Phase Ib/II	Dexamethasone Elotuzumab Filgrastim Melphalan Lenalidomide	Study of Umbilical Cord Blood-derived Natural Killer Cells in Conjunction With High Dose Chemotherapy and Autologous Stem Cell Transplant for Patients With Multiple Myeloma	Completed	USA	0
NCT01863550	Phase III	Dexamethasone Lenalidomide Carfilzomib Bortezomib	Bortezomib or Carfilzomib With Lenalidomide and Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma	Active, not recruiting	USA	1
NCT02352558	Phase I	Imatinib Napabucasin Bortezomib Ibrutinib Dexamethasone	A Study of BBI608 in Adult Patients With Advanced, Refractory Hematologic Malignancies	Completed	USA	0
NCT06232707	Phase III	Carfilzomib Pomalidomide Elotuzumab Dexamethasone Daratumumab CC-93269	A Study to Evaluate Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) (ALUMMINATE)	Withdrawn	USA \| TUR \| SWE \| ROU \| NOR \| ITA \| IRL \| HUN \| GRC \| GBR \| FRA \| ESP \| DEU \| CZE \| CHE \| CAN \| BRA \| BEL \| AUT \| AUS \| ARG	6
NCT00549848	Phase III	Daunorubicin + Pegaspargase + Vincristine Sulfate Cytarabine Mercaptopurine Thioguanine Clofarabine + Cyclophosphamide + Etoposide Methotrexate Dasatinib Doxorubicin Dexamethasone	Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia	Completed	USA	0
NCT02605356	Phase Ib/II	Radium Ra 223 dichloride Bortezomib Dexamethasone	Phase 1b/2 Study Testing Radium-223 Dichloride/Bortezomib/Dexamethasone Combination in Relapsed Multiple Myeloma	Withdrawn	USA \| ITA \| ISR \| GRC \| ESP \| DEU \| CAN \| BEL \| AUS	2
NCT06203912	Phase I	Cyclophosphamide Dexamethasone Isatuximab + TGF-beta-imprinted NK cells	Donor Immune Cells (TGFbi NK Cells) and Isatuximab for the Treatment of Relapsed or Refractory Multiple Myeloma	Recruiting	USA	0
NCT03020030	Phase III	Nelarabine Dexrazoxane Asparaginase Vincristine Sulfate Cyclophosphamide Cytarabine Mercaptopurine Pegaspargase Methotrexate Etoposide Doxorubicin Dexamethasone Prednisone Dasatinib Leucovorin	Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents	Active, not recruiting	USA \| CAN	0
NCT02659800	Phase I	Dexamethasone + NT-I7 Dexamethasone	Study of the Effect IL 7/ NT-I7 on CD4 Counts in Patients With High Grade Gliomas	Terminated	USA	0
NCT02279394	Phase II	Dexamethasone Elotuzumab + Lenalidomide	Trial of Combination of Elotuzumab and Lenalidomide +/- Dexamethasone in High-Risk Smoldering Multiple Myeloma	Completed	USA	0
NCT02532192	Phase I	Rituximab Cisplatin Dexamethasone Cytarabine Fluconazole Belinostat	A Phase Ib Study of Belinostat With RDHAP Chemotherapy (Dexamethasone, Cytarabine, Cisplatinum) in Adults With Relapsed or Refractory Diffuse Large B-cell Lymphoma	Withdrawn		0
NCT02589145	Phase Ib/II	Lenalidomide Pyridoxine Dexamethasone Busulfan + Melphalan Enoxaparin Rituximab Gemcitabine Vorinostat Palifermin	Lenalidomide Combined With Vorinostat/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Diffuse Large B-Cell Lymphoma of the ABC Subtype	Terminated	USA	0
NCT03418038	Phase II	Dexamethasone Carboplatin + Etoposide + Ifosfamide Carboplatin + Etoposide + Ifosfamide + Rituximab Cisplatin + Cytarabine + Dexamethasone Cisplatin + Dexamethasone + Gemcitabine Rituximab Cytarabine + Dexamethasone + Oxaliplatin Gemcitabine + Oxaliplatin Cisplatin + Cytarabine + Dexamethasone + Rituximab	Ascorbic Acid and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Lymphoma	Recruiting	USA	0
NCT02030483	Phase I	Palbociclib Dexamethasone Lenalidomide	Palbociclib in Combination With Lenalidomide and Dexamethasone for Multiple Myeloma	Terminated	USA	0
NCT03259503	Phase Ib/II	Busulfan Olaparib Vorinostat Palifermin Gemcitabine Melphalan Dexamethasone Pyridoxine Rituximab	Olaparib Combined With High-Dose Chemotherapy for Refractory Lymphomas	Active, not recruiting	USA	0
NCT03007147	Phase III	Pegaspargase Methotrexate Leucovorin Cytarabine Mercaptopurine Thioguanine Vincristine Sulfate Cyclophosphamide Imatinib Ifosfamide Dexrazoxane Daunorubicin Dexamethasone Methylprednisolone Etoposide Prednisolone Doxorubicin	Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia	Active, not recruiting	USA \| SWE \| NZL \| NLD \| ITA \| ISR \| FRA \| FIN \| DEU \| CZE \| CHE \| CAN \| BEL \| AUT \| AUS	4
NCT01846611	Phase III	Pegylated liposomal doxorubicin Dexamethasone	A Study Comparing the Combination of Trabectedin (YONDELIS) and DOXIL/CAELYX With DOXIL/CAELYX for the Treatment of Advanced-Relapsed Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer	Completed	USA \| POL \| NZL \| ISR \| GBR \| CHE \| AUS	3
NCT03117751	Phase II	Cyclophosphamide Vincristine Sulfate Idarubicin Blinatumomab Doxorubicin Clofarabine Vorinostat Ruxolitinib Prednisone Bortezomib Etoposide Dasatinib Daunorubicin Dexamethasone Rituximab Methotrexate Cytarabine Mercaptopurine Pegaspargase	Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma	Active, not recruiting	USA \| AUS	0
NCT03571321	Phase I	Pegaspargase Methotrexate Cytarabine Mercaptopurine Thioguanine Ruxolitinib Cyclophosphamide Dexamethasone Vincristine Sulfate Rituximab Doxorubicin	Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia	Recruiting	USA	0
NCT02518113	Phase Ib/II	Dexamethasone LY3039478	A Study of LY3039478 in Combination With Dexamethasone in Participants With T-ALL/T-LBL	Completed	USA \| ITA \| ISR \| FRA \| DEU	0
NCT02419495	Phase I	Cyclophosphamide Pemetrexed Disodium Eribulin Selinexor Carboplatin Paclitaxel Topotecan Dexamethasone Doxorubicin	Selinexor in Combination With Standard Chemotherapy	Terminated	USA	0
NCT02579863	Phase III	Pembrolizumab Dexamethasone Lenalidomide	Study of Lenalidomide and Dexamethasone With or Without Pembrolizumab (MK-3475) in Participants With Newly Diagnosed Treatment Naive Multiple Myeloma (MK-3475-185/KEYNOTE-185)	Terminated		0
NCT02400242	Phase I	Citarinostat Dexamethasone Pomalidomide	Study of ACY-241 Alone and in Combination With Pomalidomide and Dexamethasone in Multiple Myeloma	Terminated	USA \| GRC \| FRA \| ESP \| DEU	0
NCT02112916	Phase III	Cyclophosphamide Vincristine Sulfate Ifosfamide Pegaspargase Methotrexate Cytarabine Mercaptopurine Thioguanine Leucovorin Daunorubicin Dexamethasone Bortezomib Etoposide Doxorubicin	Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma	Active, not recruiting	USA \| NZL \| CAN \| AUS	0
NCT02419755	Phase II	Cytarabine Mercaptopurine Methotrexate Pegaspargase Vorinostat Doxorubicin Bortezomib Dexamethasone Mitoxantrone Prednisone	Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic Malignancies	Terminated	USA	0
NCT01428492	Phase I	Afuresertib Bortezomib Dexamethasone	Ph 1b Study to Evaluate GSK2110183 in Combination With Bortezomib and Dexamethasone in Subjects With Multiple Myeloma	Completed	USA \| IRL \| CAN \| AUS	1
NCT03150693	Phase III	Rituximab Doxorubicin Mercaptopurine Methotrexate Cyclophosphamide + Cytarabine Thioguanine Allopurinol Daunorubicin Dexamethasone Vincristine Sulfate Inotuzumab ozogamicin	Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia	Suspended	USA \| CAN	0
NCT02685826	Phase I	Dexamethasone Durvalumab + Lenalidomide	A Study of Durvalumab in Combination With Lenalidomide With and Without Dexamethasone in Subjects With Newly Diagnosed Multiple Myeloma	Completed	USA \| NLD \| ITA \| FIN \| ESP \| DNK \| DEU \| CAN	0
NCT03004287	Phase II	Melphalan Carfilzomib Cisplatin Cyclophosphamide Lenalidomide Dexamethasone Daratumumab Bortezomib Etoposide Doxorubicin Thalidomide	2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy	Active, not recruiting	USA	0
NCT02491411	Phase I	Enzalutamide Dexamethasone	Dexamethasone Prior to Re-treatment With Enzalutamide in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Previously Treated With Enzalutamide and Docetaxel	Terminated	USA	0
NCT01459211	Phase II	Dexamethasone Lenalidomide	Pilot Study to Establish Safety and Efficacy of a Combination of Dexamethasone and Lenalidomide in Patients With Relapsed or Refractory Chronic Lymphocytic Leukaemia (CLL)	Completed	GBR	0
NCT02906332	Phase II	Pembrolizumab Dexamethasone	Pembrolizumab + Lenalidomide Post Autologous Stem Cell Transplant (ASCT) in High-risk Multiple Myeloma (MM)	Terminated	USA	0
NCT03626922	Phase I	Folic Acid Cyanocobalamin Oxaliplatin + Pembrolizumab + Pemetrexed Disodium Dexamethasone Pembrolizumab + Pemetrexed Disodium	Study of Pembrolizumab With Pemetrexed and Oxaliplatin in Chemo-Refractory Metastatic Colorectal Cancer Patients	Unknown status	USA	0
NCT05848687	Phase Ib/II	Bortezomib Dexamethasone Blinatumomab Vorinostat Mercaptopurine Pegaspargase Methotrexate Ziftomenib Mitoxantrone	TINI 2: Total Therapy for Infants with Acute Lymphoblastic Leukemia II	Recruiting	USA \| CAN	0
NCT02265510	Phase I	Gemcitabine Carfilzomib Dexamethasone Lenalidomide Nab-paclitaxel Azacitidine INCB052793 Bortezomib	An Open-Label Study of a Novel JAK-inhibitor, INCB052793, Given to Patients With Advanced Malignancies	Terminated	USA	0
NCT02576977	Phase III	Pomalidomide Pembrolizumab Dexamethasone	Study of Pomalidomide and Low Dose Dexamethasone With or Without Pembrolizumab (MK-3475) in Refractory or Relapsed and Refractory Multiple Myeloma (rrMM) (MK-3475-183/KEYNOTE-183)	Terminated		0
NCT02506959	Phase II	Dexamethasone Busulfan + Melphalan Pyridoxine Panobinostat Palifermin Gemcitabine	Panobinostat Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant for Patients With Refractory/Relapsed Myeloma	Completed	USA	0
NCT02427620	Phase II	Cyclophosphamide + Doxorubicin + Vincristine Sulfate Filgrastim Dexamethasone Cytarabine + Methotrexate Leucovorin	A Study of Ibrutinib Plus Rituximab With Hyper-CVAD Consolidation in Newly Diagnosed Young Patients With Mantle Cell Lymphoma	Active, not recruiting	USA	0
NCT02036502	Phase I	Dexamethasone Lenalidomide + Pembrolizumab	A Study of Pembrolizumab (MK-3475) in Combination With Lenalidomide and Dexamethasone in Participants With Multiple Myeloma (MK-3475-023/KEYNOTE-023)	Terminated		0
NCT02211014	Phase I	Acalabrutinib Dexamethasone	An Open-Label, Phase 1b Study of ACP-196 With and Without Dexamethasone in Subjects With Multiple Myeloma	Completed	USA \| GBR	0
NCT06208150	Phase III	Dexamethasone + Elotuzumab + Pomalidomide Bortezomib + Dexamethasone + Pomalidomide Talquetamab-tgvs + Teclistamab Pomalidomide + Talquetamab-tgvs Dexamethasone	A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide (MonumenTAL-6)	Recruiting	USA \| TUR \| SWE \| POL \| NLD \| ITA \| ISR \| HUN \| GRC \| GBR \| FRA \| ESP \| DNK \| DEU \| CZE \| CAN \| BRA \| BEL \| AUT \| AUS \| ARG	5
NCT02553460	Phase II	Cyclophosphamide Mitoxantrone Dexamethasone Bortezomib Etoposide Vincristine Sulfate Pegaspargase Vorinostat Cytarabine Methotrexate Leucovorin	Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I	Active, not recruiting	USA \| CAN	0
NCT02471911	Phase I	Dexamethasone Carboplatin + Etoposide + Ifosfamide + Rituximab Selinexor	KPT-330 Plus RICE for Relapsed/Refractory Aggressive B-Cell Lymphoma	Completed	USA	0
NCT02490878	Phase II	Dexamethasone Prednisone Bevacizumab	Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases	Terminated	USA \| CAN	0
NCT01962792	Phase Ib/II	Carfilzomib + Ibrutinib Dexamethasone	Study of the Bruton's Tyrosine Kinase Inhibitor in Combination With Carfilzomib (Kyprolis), in Subjects With Relapsed or Relapsed and Refractory Multiple Myeloma	Completed	USA \| CAN	0
NCT02616640	Phase I	Pomalidomide Dexamethasone Durvalumab	A Study to Determine Dose and Regimen of Durvalumab as Monotherapy or in Combination With Pomalidomide With or Without Dexamethasone in Subjects With Relapsed and Refractory Multiple Myeloma	Completed	USA \| NLD \| ITA \| FRA \| ESP \| DEU \| CAN	0
NCT02881086	Phase III	Rituximab Doxorubicin Cytarabine Mercaptopurine Nelarabine Methotrexate Pegaspargase Cyclophosphamide Vindesine Vincristine Sulfate Daunorubicin Dexamethasone	Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment	Completed	DEU	0
NCT06216158	Phase III	Iberdomide Iberdomide + Isatuximab Dexamethasone	Iberdomide vs. Iberdomide Plus Isatuximab Maintenance Therapy Post ASCT in Newly Diagnosed Multiple Myeloma	Recruiting	DEU	0
NCT02420860	Phase II	Famotidine Elotuzumab + Lenalidomide Diphenhydramine Dexamethasone	Study of Elotuzumab With Lenalidomide as Maintenance After Autologous Stem Cell Transplant (ASCT)	Active, not recruiting	USA	0
NCT01455389	Phase Ib/II	Quaratusugene Ozeplasmid Erlotinib Diphenhydramine Dexamethasone	FUS1-nanoparticles and Erlotinib in Stage IV Lung Cancer	Terminated	USA	0
NCT02520115	Phase I	Dexamethasone Valproic acid	Folate Receptor in Diagnosing Ovarian Cancer Using Serum Samples From Patients With Newly Diagnosed Pelvic Mass or Previously Diagnosed Ovarian Cancer	Completed	USA	0
NCT01363817	Phase I	Dexamethasone BMS-906024	Study to Evaluate the Safety and Tolerability of Weekly Intravenous (IV) Doses of BMS-906024 in Subjects With Acute T-cell Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma	Completed	USA \| FRA \| DEU	0
NCT01983969	Phase Ib/II	Rituximab Dexamethasone Busulfan + Melphalan Azacitidine + Gemcitabine + Vorinostat	Aza-SAHA-GBM With AutoSCT for Refractory Lymphoma	Completed	USA	0
NCT03411031	Phase II	Elotuzumab + Lenalidomide Dexamethasone	Elotuzumab Plus Lenalidomide (Elo/Rev) for Serologic Relapse/Progression While on Lenalidomide	Terminated	USA	0
NCT01256398	Phase II	Dexamethasone Dasatinib Tacrolimus Cyclophosphamide + Fludarabine Filgrastim Mercaptopurine + Methotrexate + Vincristine Sulfate Melphalan Cytarabine + Daunorubicin + Etoposide Pegfilgrastim Alemtuzumab Leucovorin	Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	Completed	USA	0
NCT02464657	Phase Ib/II	Dexamethasone Cytarabine + Idarubicin + Nivolumab	Nivolumab in Acute Myeloid Leukemia (AML)	Completed	USA	0
NCT01483690	Phase Ib/II	Pegaspargase Methotrexate Dexamethasone Vincristine Sulfate Decitabine Mitoxantrone	A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL	Terminated	USA \| AUS	0
NCT04037462	Phase Ib/II	Dexamethasone	Induction of Sensecence Using Dexamethasone to Re-sensitize NSCLC to Anti-PD1 Therapy	Terminated	USA	0
NCT01319981	Phase II	Pegfilgrastim Imatinib Filgrastim Rituximab Doxorubicin Dexamethasone Vincristine Sulfate Cyclophosphamide	Hyper-CVAD With Liposomal Vincristine in Acute Lymphoblastic Leukemia	Completed	USA	0
NCT03860844	Phase II	Idarubicin Cyclophosphamide Isatuximab Doxorubicin Etoposide Daunoxome Cytarabine Methotrexate Daunorubicin Fludarabine Dexamethasone Mitoxantrone Filgrastim Vincristine Sulfate Pegaspargase	Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia	Terminated	USA \| SWE \| NOR \| NLD \| ITA \| HUN \| GRC \| FRA \| DNK \| DEU \| BRA \| ARG	4

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