AGI-5198
Drug Detail
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| Drug Name | AGI-5198 |
| Trade Name | |
| Synonyms | AG5198|AGI 5198|IDH-C35 |
| Drug Descriptions |
AGI-5198 is a selective inhibitor of mutant forms of IDH1, which decreases production of R-2HG, potentially leading to reduced growth of IDH1-mutant tumor cells (PMID: 23558169, PMID: 26368816, PMID: 31151327). |
| DrugClasses | IDH1 Inhibitor 8 |
| CAS Registry Number | 1355326-35-0 |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| AGI-5198 | AGI-5198 | 4 | 0 |
| AGI-5198 + Crenolanib | AGI-5198 Crenolanib | 3 | 0 |
| AGI-5198 + Metformin | AGI-5198 Metformin | 1 | 0 |
| AGI-5198 + Olaparib | AGI-5198 Olaparib | 1 | 0 |
| AGI-5198 + Radiotherapy | AGI-5198 Radiotherapy | 1 | 0 |
| AGI-5198 + Talazoparib | AGI-5198 Talazoparib | 2 | 0 |
| AGI-5198 + Trichostatin A | AGI-5198 Trichostatin A | 1 | 0 |
| AGI-5198 + Vorinostat | AGI-5198 Vorinostat | 1 | 0 |
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