Therapy Detail
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| Therapy Name | Birinapant |
| Synonyms | |
| Therapy Description |
TL32711 (birinapant) is a a bivalent SMAC-mimetic compound, which binds to and inhibits Inhibitor of Apoptosis proteins (IAPs), leading to tumor cell death (PMID: 24563541, PMID: 26566079). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Birinapant | TL32711 | SMAC Mimetic 8 | TL32711 (birinapant) is a a bivalent SMAC-mimetic compound, which binds to and inhibits Inhibitor of Apoptosis proteins (IAPs), leading to tumor cell death (PMID: 24563541, PMID: 26566079). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN loss | glioblastoma | predicted - sensitive | Birinapant | Preclinical - Cell culture | Actionable | In a preclinical study, TL32711 (birinapant) treatment inhibited proliferation of PTEN-deficient glioblastoma cells in culture (PMID: 32737157). | 32737157 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03803774 | Phase I | Birinapant | Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma | Active, not recruiting | USA | 0 |
| NCT01940172 | Phase I | Conatumumab Birinapant | Study of Birinapant in Combination With Conatumumab in Subjects With Relapsed Ovarian Cancer | Completed | USA | 0 |
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