Therapy Detail
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| Therapy Name | Entospletinib + Tirabrutinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Entospletinib | GS-9973|GS 9973|GS9973 | SYK Inhibitor 15 | Entospletinib (GS-9973) is a selective spleen tyrosine kinase (Syk) inhibitor, which in turn inhibits B-cell receptor signaling, leading to suppression of cell migration and inhibition of survival (PMID: 24779514, PMID: 32156743). | |
| Tirabrutinib | ONO-GS-4059|ONO-WG-307|ONO-4059|GS 4059|GS4059 | BTK inhibitor 38 | Tirabrutinib (ONO-4059) is a selective inhibitor of BTK, which potentially induces antibody-dependent cell-mediated cytotoxicity against tumor cells and inhibits tumor growth (PMID: 27684575, PMID: 27776353, PMID: 32583848). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02457598 | Phase I | Entospletinib + Tirabrutinib Tirabrutinib Idelalisib + Obinutuzumab + Tirabrutinib Entospletinib + Obinutuzumab + Tirabrutinib Idelalisib + Tirabrutinib | Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies | Terminated | USA | GBR | FRA | 0 |
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