Therapy Detail
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| Therapy Name | Olaratumab |
| Synonyms | |
| Therapy Description |
Lartruvo (olaratumab) is a monoclonal antibody that targets PDGFR-alpha and prevents ligand binding, potentially leading to decreased angiogenesis and reduced proliferation of tumor cells (PMID: 27291997). Lartruvo (olaratumab) in combination with doxorubicin is FDA approved for patients with soft tissue sarcoma (FDA.gov). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Olaratumab | Lartruvo | IMC-3G3 | PDGFRA Antibody 2 | Lartruvo (olaratumab) is a monoclonal antibody that targets PDGFR-alpha and prevents ligand binding, potentially leading to decreased angiogenesis and reduced proliferation of tumor cells (PMID: 27291997). Lartruvo (olaratumab) in combination with doxorubicin is FDA approved for patients with soft tissue sarcoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03994627 | Expanded access | Olaratumab | Olaratumab (LY3012207) Patient Access for Soft Tissue Sarcoma | Approved for marketing | USA | ITA | HUN | GBR | ESP | CAN | BRA | AUT | 3 |
| NCT02659020 | Phase Ib/II | Olaratumab Docetaxel + Gemcitabine | A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma | Completed | USA | POL | ITA | ISR | HUN | GBR | FRA | ESP | DEU | AUS | 0 |
| NCT02677116 | Phase I | Doxorubicin Ifosfamide Irinotecan + Vincristine Sulfate Olaratumab | A Study of Olaratumab Alone and in Combination With Standard Chemotherapies in Children With Cancer | Completed | USA | 1 |
| NCT02451943 | Phase III | Olaratumab Doxorubicin | A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue Sarcoma | Completed | USA | SWE | POL | NLD | ITA | ISR | HUN | GBR | FRA | FIN | ESP | DNK | DEU | CHE | CAN | BRA | BEL | AUT | AUS | ARG | 5 |
| NCT03056599 | Phase I | Pembrolizumab Avelumab Interferon gamma Olaratumab Trabectedin Nivolumab Gemcitabine Interferon alpha-2b Doxorubicin Atezolizumab Eribulin Ipilimumab Durvalumab Aldesleukin Bortezomib Docetaxel | Precise Local Injection of Anti-cancer Drugs Using Presage's CIVO™ Device in Soft Tissue Sarcoma | Completed | USA | 0 |
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