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Therapy Detail

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Therapy Name Docetaxel + Gemcitabine
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Docetaxel Taxotere RP56976 Antimicrotubule Agent 14 Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (PMID: 32496783, PMID: 32366558).
Gemcitabine Gemzar Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 Chemotherapy - Antimetabolite 14 Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02045446 Phase II Bevacizumab + Erlotinib Docetaxel + Gemcitabine Maintenance Chemotherapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Chemotherapy for Stage IV Non-Small Cell Lung Cancer (NSCLC) Completed USA 0
NCT06632327 Phase III Docetaxel + Gemcitabine + Nivolumab Cisplatin + Nivolumab + Pemetrexed Disodium Pembrolizumab Carboplatin + Pembrolizumab + Vinorelbine Carboplatin + Nivolumab + Vinorelbine Carboplatin + Gemcitabine Atezolizumab + Carboplatin + Gemcitabine Docetaxel + Gemcitabine Nivolumab Carboplatin + Nivolumab + Pemetrexed Disodium Atezolizumab + Cisplatin + Gemcitabine Atezolizumab + Cisplatin + Pemetrexed Disodium Cisplatin + Gemcitabine + Nivolumab Atezolizumab + Cisplatin + Vinorelbine Cisplatin + Pembrolizumab + Pemetrexed Disodium Atezolizumab + Carboplatin + Vinorelbine Atezolizumab + Docetaxel + Gemcitabine Cisplatin + Pemetrexed Disodium Carboplatin + Pemetrexed Disodium Carboplatin + Pembrolizumab + Pemetrexed Disodium Cisplatin + Gemcitabine Carboplatin + Gemcitabine + Nivolumab Atezolizumab Carboplatin + Gemcitabine + Pembrolizumab Carboplatin + Vinorelbine Docetaxel + Gemcitabine + Pembrolizumab Cisplatin + Gemcitabine + Pembrolizumab Cisplatin + Vinorelbine Cisplatin + Pembrolizumab + Vinorelbine Atezolizumab + Carboplatin + Pemetrexed Disodium Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer Recruiting USA 0
NCT04145700 Phase Ib/II Docetaxel + Gemcitabine + Ramucirumab Docetaxel + Gemcitabine CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Synovial Sarcoma Terminated USA | NLD | ITA | GBR | FRA | ESP | DEU | BEL | AUS 1
NCT02511132 Phase II FANG vaccine Docetaxel + Gemcitabine FANG vaccine + Irinotecan + Temozolomide A Two-part Phase IIb Trial of Vigil in Ewing's Sarcoma Completed USA 0
NCT05999994 Phase II Docetaxel + Gemcitabine + Ramucirumab Cyclophosphamide + Ramucirumab + Vinorelbine Cyclophosphamide + Vinorelbine Irinotecan + Temozolomide Abemaciclib + Irinotecan + Temozolomide Docetaxel + Gemcitabine A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer (CAMPFIRE) Recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | BEL | AUS 1
NCT02659020 Phase Ib/II Olaratumab Docetaxel + Gemcitabine A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma Completed USA | POL | ITA | ISR | HUN | GBR | FRA | ESP | DEU | AUS 0
NCT06498648 Phase Ib/II Abemaciclib + Gemcitabine Docetaxel + Gemcitabine Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma Suspended USA 0
NCT01593748 Phase II Docetaxel + Gemcitabine Gemcitabine + Pazopanib A Treatment Trial Comparing Gemcitabine and Pazopanib Versus Gemcitabine and Docetaxel for Patients With Advanced Soft Tissue Sarcoma Completed USA 0
NCT05712694 Phase III ADI-PEG 20 + Docetaxel + Gemcitabine Docetaxel + Gemcitabine Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC) Recruiting USA | CAN 1
NCT02049905 Phase III Dacarbazine Doxorubicin Ifosfamide Pazopanib Aldoxorubicin Docetaxel + Gemcitabine Phase 3 Study to Treat Patients With Soft Tissue Sarcomas Completed USA | POL | NLD | ITA | ISR | HUN | FRA | ESP | DNK | CAN | AUS 2
NCT03971474 Phase II Docetaxel + Gemcitabine + Pemetrexed Disodium Docetaxel + Ramucirumab Docetaxel + Gemcitabine Pembrolizumab + Ramucirumab Ramucirumab and Pembrolizumab Versus Standard of Care in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Non-Match Treatment Trial) Completed USA 0


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