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Therapy Name	TAK-632
Synonyms
Therapy Description	TAK-632 is an inhibitor of Raf, which has been shown to suppress the kinase activity of the Raf dimer thereby resulting in diminished paradoxical activation of Raf (PMID: 24121489, PMID: 31734178).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
TAK-632		TAK 632\|TAK632	RAF Inhibitor (Pan) 29	TAK-632 is an inhibitor of Raf, which has been shown to suppress the kinase activity of the Raf dimer thereby resulting in diminished paradoxical activation of Raf (PMID: 24121489, PMID: 31734178).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF D594G NRAS G12D	melanoma	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 inhibited proliferation of melanoma cell lines harboring both BRAF D594G and NRAS G12D in culture (PMID: 27523909).	27523909
BRAF G466E	melanoma	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 inhibited proliferation of melanoma cell lines harboring BRAF G466E in culture (PMID: 27523909).	27523909
BRAF G466V	lung non-small cell carcinoma	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 inhibited proliferation of non-small cell lung cancer cells harboring BRAF G466V in culture (PMID: 27523909).	27523909
BRAF L514V BRAF V600E	melanoma	decreased response	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, melanoma cells expressing BRAF L514V in cis with V600E demonstrated decreased response to TAK-632-induced inhibition of Erk phosphorylation and colony formation compared to cells expressing BRAF V600E in culture (PMID: 29880583).	29880583
BRAF L597V NRAS Q61K	lung non-small cell carcinoma	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 inhibited proliferation of non-small cell lung cancer cells harboring both BRAF L597V and NRAS Q61K in culture (PMID: 27523909).	27523909
BRAF V600D	melanoma	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 inhibited proliferation of melanoma cell lines harboring BRAF V600D in culture (PMID: 27523909).	27523909
BRAF V600E	thyroid cancer	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 inhibited proliferation of thyroid cancer cells harboring BRAF V600E in culture (PMID: 27523909).	27523909
BRAF V600E	melanoma	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 treatment inhibited Erk phosphorylation and reduced proliferation of a melanoma cells harboring either monomeric BRAF V600E or dimeric isoform (p61) of V600E in culture (PMID: 30559419).	30559419
BRAF V600E	melanoma	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 inhibited proliferation of melanoma cell lines harboring either monomeric BRAF V600E or dimeric isoform of V600E which conferred Zelboraf (vemurafenib)-resistance in culture (PMID: 27523909).	27523909
BRAF V600E	colorectal cancer	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 inhibited proliferation of colorectal cancer cells harboring BRAF V600E in culture (PMID: 27523909).	27523909
BRAF V600R	melanoma	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 inhibited proliferation of melanoma cell lines harboring BRAF V600R in culture (PMID: 27523909).	27523909
BRAF wild-type NRAS wild-type	melanoma	sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 inhibited proliferation of BRAF and NRAS wild-type melanoma cells in culture (PMID: 27523909).	27523909
NRAS Q61R	melanoma	predicted - sensitive	TAK-632	Preclinical - Cell culture	Actionable	In a preclinical study, TAK-632 treatment inhibited Erk activation and reduced proliferation of melanoma cells harboring NRAS Q61R and wild-type RAF in culture, but at a higher concentration than was required to inhibit melanoma cells harboring BRAF V600E (PMID: 30559419).	30559419
BRAF L485_P490delinsFS	Advanced Solid Tumor	predicted - sensitive	TAK-632	Preclinical - Biochemical	Actionable	In a preclinical study, TAK-632 inhibited Mek and Erk phosphorylation in cells expressing BRAF L485_P490delinsFS in culture (PMID: 37656784).	37656784

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