Therapy Detail
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| Therapy Name | Dexamethasone + Isatuximab + Pomalidomide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Dexamethasone | Adexone | Desametasone | ||
| Isatuximab | Sarclisa | SAR650984|isatuximab-irfc | CD38 Antibody 20 | Sarclisa (isatuximab-irfc) is a humanized monoclonal antibody against CD38 that induces anti-tumor immune reaction against CD38-positive tumor cells (PMID: 24987056). Sarclisa (isatuximab-irfc) in combination with Pomalyst (pomalidomide) and dexamethasone is FDA approved for use in patients with multiple myeloma who have received two or more prior therapies, in combination with Kyprolis (carfilzomib) and dexamethasone for patients with relapsed or refractory multiple myeloma who have received one to three prior lines of therapy, and in combination with Velcade (bortezomib), Revlimid (lenalidomide), and dexamethasone for patients with newly diagnosed multiple myeloma ineligible for transplant (FDA.gov). |
| Pomalidomide | Pomalyst | CC-4047 | Pomalyst (pomalidomide) is a thalidomide derivative that inhibits angiogenesis and modulates immune response, potentially lead to antitumor activity (PMID: 30069630). Pomalyst (pomalidomide) is FDA approved for use in patients with Kaposi's sarcoma who failed HAART or are HIV-negative, and in combination with dexamethasone in patients with multiple myeloma who had 2 or more prior therapies (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05405166 | Phase III | Dexamethasone + Isatuximab + Pomalidomide | SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM | Active, not recruiting | USA | TUR | SWE | POL | NOR | ITA | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CAN | BRA | AUS | ARG | 4 |
| NCT02283775 | Phase I | Dexamethasone + Isatuximab + Pomalidomide | SAR650984, Pomalidomide and Dexamethasone in Combination in RRMM Patients (PomdeSAR) | Completed | USA | 0 |
| NCT05911321 | Phase II | Dexamethasone + Isatuximab + Pomalidomide | Isa-Pom-Dex in Elderly/Frail Subjects With RRMM | Recruiting | USA | 0 |
| NCT04045795 | Phase I | Dexamethasone + Isatuximab + Pomalidomide | Multi-center, Open-label, Phase 1b Study in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) | Completed | USA | FRA | ESP | BEL | AUS | 1 |
| NCT02990338 | Phase III | Dexamethasone + Isatuximab + Pomalidomide Dexamethasone + Pomalidomide | Multinational Clinical Study Comparing Isatuximab, Pomalidomide, and Dexamethasone to Pomalidomide and Dexamethasone in Refractory or Relapsed and Refractory Multiple Myeloma Patients (ICARIA-MM) | Completed | USA | TUR | SWE | SVK | POL | NZL | NOR | ITA | HUN | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BEL | AUS | 5 |
| NCT05298683 | Phase II | Dexamethasone + Isatuximab + Pomalidomide | A Phase 2 Study of Isatuximab in Combination With Pomalidomide and Dexamethasone in MM Patients Who Received One Prior Line of Therapy Containing Lenalidomide and a Proteasome Inhibitor | Not yet recruiting | GRC | 0 |
| NCT04643002 | Phase Ib/II | Dexamethasone + Isatuximab + Pomalidomide Dexamethasone + Isatuximab + SAR439459 | Isatuximab in Combination With Novel Agents in RRMM | Recruiting | USA | NOR | ITA | ISR | GRC | FRA | DEU | AUS | 2 |
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