Therapy Detail
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| Therapy Name | Enzalutamide + ZEN-3694 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Enzalutamide | Xtandi | MDV3100|ASP9785 | Hormone - Anti-androgens 57 | Xtandi (enzalutamide) is a second-generation small molecule inhibitor of androgen receptor, thereby resulting in decreased tumor growth (PMID: 24009414, PMID: 25945058). Xtandi (enzalutamide) is FDA-approved for use in patients with castration-resistant prostate cancer, metastatic hormone-sensitive prostate cancer, and non-metastatic castration-sensitive prostate cancer with biochemical recurrence at high risk for metastasis (FDA.gov). |
| ZEN-3694 | ZEN003694|BETi ZEN-3694|ZEN3694|ZEN 3694 | BET Inhibitor (Pan) 33 | ZEN-3694 is a pan BET inhibitor that suppresses AR signaling, which potentially inhibits tumor progression (Cancer Res 2016;76(14 Suppl):Abstract nr LB-207, PMID: 32694156). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04986423 | Phase II | Enzalutamide + ZEN-3694 Enzalutamide | ZEN003694 and Enzalutamide Versus Enzalutamide Monotherapy in Metastatic Castration-Resistant Prostate Cancer | Recruiting | USA | 1 |
| NCT02711956 | Phase I | Enzalutamide + ZEN-3694 | A Study of ZEN003694 in Combination With Enzalutamide in Patients With Metastatic Castration-Resistant Prostate Cancer | Completed | USA | 0 |
| NCT06922318 | Phase II | Enzalutamide + ZEN-3694 Testosterone cypionate + ZEN-3694 | The COSMYC Trial (COmbined Suppression of MYC) | Recruiting | USA | 0 |
| NCT04145375 | Phase Ib/II | Enzalutamide + ZEN-3694 | Continuation Protocol for ZEN003694 in Patients Experiencing Clinical Benefit While Enrolled in a ZEN003694 Protocol | Enrolling by invitation | USA | 0 |
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