Therapy Detail
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| Therapy Name | Parsaclisib + Ruxolitinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Parsaclisib | INCB050465|INCB 50465|INCB-50465|INCB50465|WHO 10589 | PIK3CD inhibitor 27 | Parsaclisib (INCB050465) inhibits PI3K-delta, blocking activation of AKT signaling pathway and leading to apoptosis of PIK3CD expressing tumor cells (PMID: 31749910). | |
| Ruxolitinib | Jakafi | INCB 18424|INCB018424|INCB18424 | JAK1 Inhibitor - ATP competitive 5 JAK2 Inhibitor - ATP competitive 15 | Jakafi (ruxolitinib) is an inhibitor of protein tyrosine kinases JAK1 and JAK2, thus resulting in reduced inflammation and reduced proliferation (PMID: 22474318). Jakafi (ruxolitinib) is FDA approved to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis (FDA.gov) |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04551053 | Phase III | Parsaclisib + Ruxolitinib Ruxolitinib | To Evaluate Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis Who Have Suboptimal Response to Ruxolitinib (LIMBER-304) | Terminated | USA | TUR | ROU | POL | NOR | ITA | ISR | HUN | GBR | FRA | FIN | ESP | DEU | BEL | AUT | 4 |
| NCT04551066 | Phase III | Ruxolitinib Parsaclisib + Ruxolitinib | To Evaluate the Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis (LIMBER-313) | Active, not recruiting | USA | TUR | POL | NOR | ITA | ISR | GBR | FRA | FIN | ESP | DNK | DEU | BEL | AUT | 3 |
| NCT02718300 | Phase II | Parsaclisib + Ruxolitinib | A Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis | Terminated | USA | 0 |
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