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Therapy Name	CGM097 + Dabrafenib + Navitoclax + PF-04217903
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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
CGM097		NVP-CGM097	MDM2 Inhibitor 23	CGM097 binds to the p53 binding region of MDM2 and prevents MDM2-p53 interaction, resulting in activation of p53 signaling and decreased tumor growth (Cancer Res October 1, 2014 74:4638, PMID: 32651541).
Dabrafenib	Tafinlar	GSK2118436	BRAF Inhibitor 26	Tafinlar (dabrafenib) inhibits the activity of BRAF, including V600E, which results in the inhibition of tumor cell proliferation (PMID: 22735384). Tafinlar (dabrafenib) is FDA approved for BRAF V600E/K- positive unresectable or metastatic melanoma, and in combination with Mekinist (trametinib) for BRAF V600E/K-mutant melanoma, BRAF V600E-mutant non-small cell lung cancer, BRAF V600E-mutant anaplastic thyroid cancer, for adult and pediatric patients of 6 years or older with unresectable or metastatic solid tumors harboring BRAF V600E, and for pediatric patients of 1 year or older with low-grade glioma harboring BRAF V600E (FDA.gov).
Navitoclax		ABT-263	BCL-XL inhibitor 14 BCL2 inhibitor 27	Navitoclax (ABT-263) is a BCL2, BCL-XL, and BCL-W inhibitor, which may enhance the efficacy of chemotherapeutics (PMID: 25787766, PMID: 32513939).
PF-04217903		PF04217903	MET Inhibitor 59	PF-04217903 binds to MET and inhibits its activation, resulting in decreased activation of downstream signaling, and potentially resulting in decreased tumor cell growth and migration and increased tumor cell death (PMID: 28599617).

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Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF mut TP53 wild-type	colorectal cancer	sensitive	CGM097 + Dabrafenib + Navitoclax + PF-04217903	Preclinical - Cell culture	Actionable	In a preclinical study, the combination of Navitoclax (ABT-263), CGM097, Tafinlar (dabrafenib), and PF04217903 resulted in the greatest synergistic effect and inhibition of cell growth in colorectal cancer cells harboring a BRAF mutation and wild-type TP53 in culture compared to the double or triple combinations of the therapies (PMID: 27659046).	27659046

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