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Drug Name Navitoclax
Trade Name
Synonyms ABT-263
Drug Descriptions

Navitoclax (ABT-263) is a BCL2, BCL-XL, and BCL-W inhibitor, which may enhance the efficacy of chemotherapeutics (PMID: 25787766, PMID: 32513939).

DrugClasses BCL-XL inhibitor 14 BCL2 inhibitor 27
CAS Registry Number 923564-51-6
NCIT ID C64776

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABBV-744 + Navitoclax ABBV-744 Navitoclax 0 1
Abiraterone + Navitoclax Abiraterone Navitoclax 0 1
Alpelisib + CGM097 + Navitoclax + Trametinib Alpelisib CGM097 Navitoclax Trametinib 0 0
Alpelisib + Dabrafenib + Erlotinib + Navitoclax Alpelisib Dabrafenib Erlotinib Navitoclax 1 0
Alpelisib + Erlotinib + Navitoclax + Trametinib Alpelisib Erlotinib Navitoclax Trametinib 0 0
Barasertib + Navitoclax Barasertib Navitoclax 0 0
BETd-246 + Navitoclax BETd-246 Navitoclax 0 0
Buparlisib + Navitoclax Buparlisib Navitoclax 0 0
Cabozantinib + Navitoclax Cabozantinib Navitoclax 0 0
CGM097 + Dabrafenib + Navitoclax + PF-04217903 CGM097 Dabrafenib Navitoclax PF-04217903 1 0
CGM097 + Navitoclax + Trametinib CGM097 Navitoclax Trametinib 0 0
Cladribine + Cytarabine + Filgrastim + Mitoxantrone + Navitoclax + Venetoclax Cladribine Cytarabine Filgrastim Mitoxantrone Navitoclax Venetoclax 0 1
Cladribine + Cytarabine + Navitoclax + Venetoclax Cladribine Cytarabine Navitoclax Venetoclax 0 1
Crizotinib + Navitoclax Crizotinib Navitoclax 0 0
CYC065 + Navitoclax CYC065 Navitoclax 0 0
Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Leucovorin + Methotrexate + Navitoclax + Pegaspargase + Venetoclax + Vincristine Sulfate Cytarabine Dasatinib Dexamethasone Hydrocortisone Leucovorin Methotrexate Navitoclax Pegaspargase Venetoclax Vincristine Sulfate 0 1
Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Methotrexate + Navitoclax + Pegaspargase + Venetoclax Cytarabine Dasatinib Dexamethasone Hydrocortisone Methotrexate Navitoclax Pegaspargase Venetoclax 0 1
Cytarabine + Dexamethasone + Hydrocortisone + Leucovorin + Methotrexate + Navitoclax + Pegaspargase + Venetoclax + Vincristine Sulfate Cytarabine Dexamethasone Hydrocortisone Leucovorin Methotrexate Navitoclax Pegaspargase Venetoclax Vincristine Sulfate 0 1
Cytarabine + Dexamethasone + Hydrocortisone + Methotrexate + Navitoclax + Pegaspargase + Venetoclax Cytarabine Dexamethasone Hydrocortisone Methotrexate Navitoclax Pegaspargase Venetoclax 0 1
Cytarabine + Navitoclax Cytarabine Navitoclax 0 0
Dabrafenib + Navitoclax + Trametinib Dabrafenib Navitoclax Trametinib 0 1
Decitabine + Navitoclax + Venetoclax Decitabine Navitoclax Venetoclax 0 4
Everolimus + Navitoclax Everolimus Navitoclax 0 0
G-TPP + Navitoclax G-TPP Navitoclax 0 0
Gemcitabine + Navitoclax Gemcitabine Navitoclax 0 0
Ibrutinib + Navitoclax + Rituximab + Venetoclax Ibrutinib Navitoclax Rituximab Venetoclax 0 1
Infigratinib + Navitoclax Infigratinib Navitoclax 1 0
Ipatasertib + Navitoclax Ipatasertib Navitoclax 0 0
KRT-232 + Navitoclax KRT-232 Navitoclax 1 0
MIK665 + Navitoclax MIK665 Navitoclax 0 0
Mivebresib + Navitoclax Mivebresib Navitoclax 0 1
Navitoclax Navitoclax 0 2
Navitoclax + Olaparib Navitoclax Olaparib 0 1
Navitoclax + ONC201 Navitoclax ONC201 1 0
Navitoclax + Osimertinib Navitoclax Osimertinib 0 1
Navitoclax + Paclitaxel Navitoclax Paclitaxel 0 0
Navitoclax + Pictilisib Navitoclax Pictilisib 1 0
Navitoclax + PLX4720 Navitoclax PLX4720 1 0
Navitoclax + Rucaparib Navitoclax Rucaparib 0 0
Navitoclax + Ruxolitinib Navitoclax Ruxolitinib 0 3
Navitoclax + S63845 Navitoclax S63845 0 0
Navitoclax + SCH772984 Navitoclax SCH772984 0 0
Navitoclax + Sorafenib Navitoclax Sorafenib 0 1
Navitoclax + TAK-901 Navitoclax TAK-901 0 0
Navitoclax + Trametinib Navitoclax Trametinib 7 1
Navitoclax + Ulixertinib Navitoclax Ulixertinib 1 0
Navitoclax + Vemurafenib Navitoclax Vemurafenib 3 0
Navitoclax + Venetoclax Navitoclax Venetoclax 0 3
Navitoclax + Vistusertib Navitoclax Vistusertib 0 1
Navitoclax + VU661013 Navitoclax VU661013 0 0
Navitoclax + YM155 Navitoclax YM155 0 0


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