Therapy Detail
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| Therapy Name | Ciforadenant + CPI-006 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CPI-006 | CPI 006|CPI006|CPX-006 | Adenosine Targeting 24 CD73 Antibody 14 | CPI-006 is a monoclonal antibody against NT5E (CD73) that inhibits the conversion of AMP to adenosine to inhibit tumor growth and also has immunomodulatory activities (Journal of Clinical Oncology 2019 37:15_suppl, TPS2646). | |
| Ciforadenant | CPI-444|CPI 444|CPI444|V81444||V-81444 | Adenosine Targeting 24 | Ciforadenant (CPI-444) is an antagonist of the adenosine receptor A2aR, which may relieve adenosine-mediated immune suppression and enhance antitumor activity (PMID: 29923026, PMID: 30131376). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03454451 | Phase I | CPI-006 CPI-006 + Pembrolizumab Ciforadenant + CPI-006 | CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers | Completed | USA | AUS | 0 |
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