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Therapy Detail
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| Therapy Name | NZV930 |
| Synonyms | |
| Therapy Description |
NZV930 is a monoclonal antibody against NT5E (CD73), resulting in activation of an anti-tumor immune response by preventing the conversion of AMP to adenosine in the tumor microenvironment (PMID: 31461341). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| NZV930 | SRF373|SRF-373|SRF 373|NZV 930|NZV-930 | Adenosine Targeting 24 CD73 Antibody 13 | NZV930 is a monoclonal antibody against NT5E (CD73), resulting in activation of an anti-tumor immune response by preventing the conversion of AMP to adenosine in the tumor microenvironment (PMID: 31461341). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03549000 | Phase I | NZV930 + Spartalizumab + Taminadenant NZV930 + Spartalizumab NZV930 + Taminadenant NZV930 | A Phase I/Ib Study of NZV930 Alone and in Combination With PDR001 and /or NIR178 in Patients With Advanced Malignancies. | Terminated | USA | GBR | ESP | CAN | AUS | 2 |
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