Therapy Detail

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Therapy Name NZV930 + Spartalizumab + Taminadenant
Synonyms
Therapy Description

Limited information is currently available on NZV930, a putative monoclonal antibody against NT5E (CD73) (Jul 2018).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NZV930 SRF373|SRF-373|SRF 373|NZV 930|NZV-930 Adenosine Targeting 23 CD73 Antibody 12 NZV930 is a monoclonal antibody against NT5E (CD73), resulting in activation of an anti-tumor immune response by preventing the conversion of AMP to adenosine in the tumor microenvironment (PMID: 31461341).
Spartalizumab PDR001|PDR-001 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 Spartalizumab (PDR001) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 32364844, PMID: 32179633).
Taminadenant NIR178|PBF-509 Adenosine Targeting 23 Taminadenant binds to and inhibits the adenosine A2A (ADORA2A) receptor on immune cells, resulting in activation of an anti-tumor immune response by blocking binding of the immunosuppressive metabolite, adenosine (PMID: 29758241, PMID: 28582704).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03549000 Phase I NZV930 + Spartalizumab + Taminadenant NZV930 + Spartalizumab NZV930 + Taminadenant NZV930 A Phase I/Ib Study of NZV930 Alone and in Combination With PDR001 and /or NIR178 in Patients With Advanced Malignancies. Terminated USA | GBR | ESP | CAN | AUS 2


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