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Therapy Name	CART-EGFRvIII + Pembrolizumab
Synonyms
Therapy Description	CART-EGFRvIII comprises autologous T-cells engineered with a lentiviral vector to express a chimeric antigen receptor that targets EGFRvIII-expressing tumor cells, which may have anti-tumor activity (PMID: 25696001, PMID: 25696001).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
CART-EGFRvIII				CART-EGFRvIII comprises autologous T-cells engineered with a lentiviral vector to express a chimeric antigen receptor that targets EGFRvIII-expressing tumor cells, which may have anti-tumor activity (PMID: 25696001, PMID: 28724573).
Pembrolizumab	Keytruda	MK-3475	Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 131	Keytruda (pembrolizumab) is an antibody against PD-1 that activates T-cell mediated anti-tumor immune response (PMID: 25977344). Keytruda (pembrolizumab) is approved in melanoma, SCLC, HNSCC, classical Hodgkin Lymphoma, PMBL, urothelial carcinoma, HCC, Merkel cell carcinoma, NMIBC, cutaneous SCC, MSI-H or dMMR or TMB high advanced solid tumors, NSCLC and CD274 (PD-L1)-positive NSCLC, esophageal SCC, cervical cancer, HNSCC, and TNBC, in combination with platnum-based chemo in NSCLC, with pemetrexed and platinum in pleural mesothelioma and non-sNSCLC with no EGFR or ALK mutations, with carboplatin and paclitaxel/nab-paclitaxel in sNSCLC, with axitinib or lenvatinib in RCC, with lenvatinib in endometrial carcinoma that is not MSI-H or dMMR, in combination with platinum and fluoropyrimidine-based chemo for esophageal or gastroesophageal carcinoma, in combination with Herceptin (trastuzumab), fluoropyrimidine- and platinum-containing chemo for CD274 (PD-L1)-positive, HER2-positive gastric or GEJ adenocarcinoma, in combination with fluoropyrimidine- and platinum-containing chemo for HER2-negative gastric or GEJ adenocarcinoma, in combination with platinum-based chemotherapy, with or without bevacizumab, for patients with CD274 (PD-L1)-positive (CPS>=1) cervical cancer, in combination with gemcitabine and cisplatin for biliary tract cancer, in combination with chemoradiation for cervical cancer, and in combination with carboplatin and paclitaxel for endometrial carcinoma (FDA.gov).

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT03726515	Phase I	CART-EGFRvIII + Pembrolizumab	CART-EGFRvIII + Pembrolizumab in GBM	Completed	USA	0

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