Therapy Detail
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| Therapy Name | Bortezomib + Dexamethasone + Melflufen |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bortezomib | Velcade | Velcade (bortezomib) is a reversible proteasome inhibitor that inhibits survival of malignant cells and regulates bone remodeling (PMID: 26579531). Velcade (bortezomib) is FDA approved for the treatment of mantle cell lymphoma and multiple myeloma (FDA.gov). | ||
| Dexamethasone | Adexone | Desametasone | ||
| Melflufen | mel-flufen|Melphalan Flufenamide | Chemotherapy - Alkylating 18 | Melflufen (Melphalan Flufenamide) is a lipophilic alkylating agent that induces DNA damage, potentially resulting in increased tumor cell death (PMID: 27098276, PMID: 29029544). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03481556 | Phase Ib/II | Bortezomib + Dexamethasone + Melflufen Daratumumab + Dexamethasone + Melflufen | Study of Melflufen + Dex With Bortezomib or Daratumumab in Patients With RRMM (ANCHOR) | Terminated | USA | FRA | ESP | CZE | 0 |
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