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Therapy Name Daratumumab + Dexamethasone + Melflufen
Synonyms
Therapy Description

Melflufen is a prodrug that releases Melphalan, a DNA alkylating agent, by peptidases overexpressed in cancer cells, and may inhibit proliferation of tumor cells (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Daratumumab Darzalex JNJ-54767414 CD38 Antibody 20 Darzalex (Daratumumab) is a human antibody against CD38 that induces antibody-dependent cell-mediated cytotoxicity and complement-mediated cytotoxicity against CD38-positive tumor cells (PMID: 30546360). Darzalex (Daratumumab) is FDA approved for multiple myeloma patients as a monotherapy or in combination with lenalidomide and dexamethasone, or with bortezomib and dexamethasone, or with bortezomib, melphalan, and prednisone, or with pomalidomide and dexamethasone, or with bortezomib, thalidomide and dexamethasone (FDA.gov).
Dexamethasone Adexone Desametasone
Melflufen mel-flufen|Melphalan Flufenamide Chemotherapy - Alkylating 18 Melflufen (Melphalan Flufenamide) is a lipophilic alkylating agent that induces DNA damage, potentially resulting in increased tumor cell death (PMID: 27098276, PMID: 29029544).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03481556 Phase Ib/II Bortezomib + Dexamethasone + Melflufen Daratumumab + Dexamethasone + Melflufen Study of Melflufen + Dex With Bortezomib or Daratumumab in Patients With RRMM (ANCHOR) Terminated USA | FRA | ESP | CZE 0
NCT04649060 Phase III Daratumumab + Dexamethasone + Melflufen Daratumumab Study of Melphalan Flufenamide (Melflufen) in Combination With Daratumumab in Relapsed Refractory Multiple Myeloma (LIGHTHOUSE) Terminated POL | NOR | GRC | ESP | DEU | CZE | BGR 4


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