Therapy Detail
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| Therapy Name | RP1 |
| Synonyms | |
| Therapy Description |
RP1 is an engineered oncolytic type-I herpes simplex virus (HSV-1) strain that expresses a fusogenic glycoprotein (GALV-GP-R-) and GM-CSF, which potentially induces an anti-tumor immune response and tumor cell lysis (Cancer Res (2024) 84 (7_Supplement): CT003, NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| RP1 | Vusolimogene Oderparepvec|HSV-1 Engineered RP1|HSV-1 Oncolytic Viral Strain RP1 | RP1 is an engineered oncolytic type-I herpes simplex virus (HSV-1) strain that expresses a fusogenic glycoprotein (GALV-GP-R-) and GM-CSF, which potentially induces an anti-tumor immune response and tumor cell lysis (Cancer Res (2024) 84 (7_Supplement): CT003, NCI Drug Dictionary). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05858229 | Phase Ib/II | RP1 | Neo-adjuvant Treatment for Squamous Cell Carcinoma Using Direct Tumor Injection With RP1. | Recruiting | USA | 0 |
| NCT04050436 | Phase II | Cemiplimab + RP1 RP1 | Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer (CERPASS) | Active, not recruiting | USA | POL | ITA | GRC | FRA | ESP | DEU | CAN | BGR | AUS | 0 |
| NCT06216938 | Phase I | RP1 | RP1 in Primary Melanoma to Reduce the Risk of Sentinel Lymph Node Metastasis | Recruiting | USA | 0 |
| NCT04349436 | Phase Ib/II | RP1 | A Phase 1B/2 Study of RP1 in Solid Organ Transplant Patients With Advanced Cutaneous Malignancies (ARTACUS) | Recruiting | USA | 0 |
| NCT03767348 | Phase Ib/II | Nivolumab + RP1 RP1 | Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE) | Recruiting | USA | GBR | FRA | ESP | DEU | 0 |
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