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Drug Name | RP1 |
Trade Name | |
Synonyms | Vusolimogene Oderparepvec|HSV-1 Engineered RP1|HSV-1 Oncolytic Viral Strain RP1 |
Drug Descriptions |
RP1 is an engineered oncolytic type-I herpes simplex virus (HSV-1) strain that expresses a fusogenic glycoprotein (GALV-GP-R-) and GM-CSF, which potentially induces an anti-tumor immune response and tumor cell lysis (Cancer Res (2024) 84 (7_Supplement): CT003, NCI Drug Dictionary). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C158074 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + RP1 | Atezolizumab RP1 | 0 | 1 |
Cemiplimab + RP1 | Cemiplimab RP1 | 0 | 1 |
Nivolumab + RP1 | Nivolumab RP1 | 0 | 2 |
RP1 | RP1 | 0 | 4 |