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Drug Name RP1
Trade Name
Synonyms Vusolimogene Oderparepvec|HSV-1 Engineered RP1|HSV-1 Oncolytic Viral Strain RP1
Drug Descriptions

RP1 is an engineered oncolytic type-I herpes simplex virus (HSV-1) strain that expresses a fusogenic glycoprotein (GALV-GP-R-) and GM-CSF, which potentially induces an anti-tumor immune response and tumor cell lysis (Cancer Res (2024) 84 (7_Supplement): CT003, NCI Drug Dictionary).

DrugClasses
CAS Registry Number NA
NCIT ID C158074

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + RP1 Atezolizumab RP1 0 1
Cemiplimab + RP1 Cemiplimab RP1 0 1
Nivolumab + RP1 Nivolumab RP1 0 2
RP1 RP1 0 4


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