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Therapy Name Nivolumab + Vusolimogene oderparepvec
Synonyms
Therapy Description

Limited information is currently available on RP1 (Feb, 2019).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Nivolumab Opdivo MDX-1106|BMS-936558 Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 138 Opdivo (nivolumab) is an antibody that targets PD-1 (PDCD1), which results in increased T-cell activation and enhanced anti-tumor immune response (PMID: 28891423). Opdivo (nivolumab) is FDA approved for use as a monotherapy in patients with non-small cell lung cancer (NSCLC) progressed on prior therapies, Hodgkin's lymphoma, head and neck squamous cell carcinoma, urothelial carcinoma (UC) , esophageal squamous cell carcinoma, resected esophageal or gastroesophageal junction (GEJ) cancer, as a monotherapy or in combination with Yervoy (ipilimumab) for melanoma, renal cell carcinoma (RCC), microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer (including patients 12 years or older), and hepatocellular carcinoma, in combination with Yervoy (ipilimumab) as first-line therapy for PD-L1-positive (>=1%) metastatic NSCLC without EGFR or ALK alterations, with Yervoy (ipilimumab) and platinum-based chemotherapy as first-line therapy for metastatic or recurrent NSCLC without EGFR or ALK alterations, with platinum doublet chemotherapy as neoadjuvant treatment for patients with resectable NSCLC, with Cabometyx (cabozantinib) for advanced RCC, with fluoropyrimidine- and platinum-containing chemotherapy for advanced or metastatic gastric cancer, GEJ cancer, and esophageal adenocarcinoma, with cisplatin and gemcitabine as first-line therapy for unresectable or metastatic UC, and with AVD for Hodgkin's lymphoma (FDA.gov).
Vusolimogene oderparepvec Tudriqev vusolimogene oderparepvec-wtpg|RP1|HSV-1 Engineered RP1 Tudriqev (vusolimogene oderparepvec) is an engineered oncolytic type-I herpes simplex virus (HSV-1) strain that expresses a fusogenic glycoprotein (GALV-GP-R-) and GM-CSF, which potentially induces an anti-tumor immune response and tumor cell lysis (Cancer Res (2024) 84 (7_Supplement): CT003, NCI Drug Dictionary). Tudriqev (vusolimogene oderparepvec) is FDA-approved for use in combination with nivolumab for patients with unresectable advanced cutaneous melanoma who have progressed on a PD-1 inhibitor therapy (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03767348 Phase II Nivolumab + Vusolimogene oderparepvec Vusolimogene oderparepvec Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE) (IGNYTE) Active, not recruiting USA | GBR | FRA | ESP | DEU 0
NCT06264180 Phase III Nab-paclitaxel Nivolumab + Vusolimogene oderparepvec Paclitaxel Nivolumab and relatlimab-rmbw Nivolumab Dacarbazine Pembrolizumab Temozolomide VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs (IGNYTE-3) Recruiting USA | POL | GRC | GBR | FRA | ESP | DEU 0


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