Therapy Detail

Filtering

Case insensitive filtering will display rows if any text in any cell matches the filter term
Use simple literal full or partial string matches
Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
Click on any column header arrows to sort by that column
Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Filter rows:

Showing 1 to 1 of 1 entries

Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
AZD3229		AZD-3229\|AZD 3229	KIT Inhibitor 57 PDGFR-alpha Inhibitor 10	AZD3229 is an inhibitor of Kit and Pdgfra that may have anti-tumor activity against KIT/PDGFRA-driven tumors and may also be effective against acquired resistance mutations seen with other Kit/Pdgfra inhibitors (PMID: 32350132, PMID: 32220888).

Showing 1 to 1 of 1 entries

Filter rows:

Filtering

Case insensitive filtering will display rows if any text in any cell matches the filter term
Use simple literal full or partial string matches
Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
Click on any column header arrows to sort by that column
Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Filter rows:

Showing 1 to 20 of 20 entries

Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT K642E KIT N822K	gastrointestinal stromal tumor	sensitive	AZD3229	Preclinical - Pdx	Actionable	In a preclinical study, AZD3229 inhibited Kit signaling and tumor growth in a patient-derived xenograft (PDX) model of gastrointestinal stromal tumor harboring KIT K642E and KIT N822K (PMID: 32350132).	32350132
KIT W557_K558del KIT V654A	gastrointestinal stromal tumor	sensitive	AZD3229	Preclinical - Pdx	Actionable	In a preclinical study, AZD3229 inhibited Kit signaling and tumor growth in a patient-derived xenograft (PDX) model of gastrointestinal stromal tumor harboring KIT W557_K558del and KIT V654A, which was established from a patient who did not respond to Gleevec (imatinib) treatment (PMID: 32350132).	32350132
KIT W557_K558del KIT Y823D	gastrointestinal stromal tumor	sensitive	AZD3229	Preclinical - Pdx	Actionable	In a preclinical study, AZD3229 inhibited Kit signaling and tumor growth in a patient-derived xenograft (PDX) model of gastrointestinal stromal tumor harboring KIT W557_K558del and KIT Y823D (PMID: 32350132).	32350132
KIT V560_Y578del KIT V654A	gastrointestinal stromal tumor	sensitive	AZD3229	Preclinical - Cell line xenograft	Actionable	In a preclinical study, AZD3229 suppressed Kit signaling and cell growth in culture, and inhibited tumor growth in a cell line xenograft model of gastrointestinal stromal tumor harboring KIT V560_Y578del and KIT V654A (PMID: 32350132).	32350132
KIT W557_K558del KIT D816H	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell line xenograft	Actionable	In a preclinical study, AZD3229 inhibited growth of cells in culture and tumor growth in a cell line xenograft model of transformed cells expressing KIT W557_K558del and KIT D816H (PMID: 32350132).	32350132
KIT W557_K558del KIT V654A	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell line xenograft	Actionable	In a preclinical study, transformed cells expressing KIT W557_K558del and KIT V654A demonstrated sensitivity to treatment with AZD3229 in both culture and cell line xenograft models, resulting in reduced cell viability, decreased KIT signaling, and tumor regression (PMID: 32350132).	32350132
KIT A502_Y503dup	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT A502_Y503dup demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability and inhibition of KIT signaling (PMID: 32350132).	32350132
KIT A502_Y503dup KIT D816H	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT A502_Y503dup and KIT D816H demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT A502_Y503dup KIT V654A	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT A502_Y503dup and KIT V654A demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT V560_Y578del	gastrointestinal stromal tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, AZD3229 inhibited cell growth and KIT signaling in a gastrointestinal stromal tumor cell line harboring KIT V560_Y578del in culture (PMID: 32350132).	32350132
KIT V560D	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT V560D demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT V560D KIT D816H	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT V560D and KIT D816H demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT V560D KIT D820A	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT V560D and KIT D820A demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT V560D KIT V654A	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT V560D and KIT V654A demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT W557_K558del	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT W557_K558del demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT W557_K558del KIT A829P	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT W557_K558del and KIT A829P demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT W557_K558del KIT D820A	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT W557_K558del and KIT D820A demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT W557_K558del KIT N822K	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT W557_K558del and KIT N822K demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT W557_K558del KIT T670I	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT W557_K558del and KIT T670I demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132
KIT W557_K558del KIT Y823D	Advanced Solid Tumor	sensitive	AZD3229	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing KIT W557_K558del and KIT Y823D demonstrated sensitivity to AZD3229 in culture, resulting in reduced cell viability (PMID: 32350132).	32350132

Showing 1 to 20 of 20 entries

Filter rows:

Filtering

Case insensitive filtering will display rows if any text in any cell matches the filter term
Use simple literal full or partial string matches
Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
Click on any column header arrows to sort by that column
Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Filter rows:

Showing 0 to 0 of 0 entries

Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
No data available in table

Filter rows:

Therapy Detail

Contact

Filtering

Sorting

Filtering

Sorting

Filtering

Sorting

Additional content available in CKB BOOST