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Therapy Name	ERAS-007
Synonyms
Therapy Description	ERAS-007 (ASN007) is a small molecule that inhibits ERK1/2, which may result in decreased tumor cell proliferation and reduced tumor growth (PMID: 34337566).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
ERAS-007		ASN007\|ASN-007\|ASN 007\|ERAS007\|ERAS 007	ERK Inhibitor (pan) 21	ERAS-007 (ASN007) is a small molecule that inhibits ERK1/2, which may result in decreased tumor cell proliferation and reduced tumor growth (PMID: 34337566).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF V600E	melanoma	sensitive	ERAS-007	Preclinical - Pdx & cell culture	Actionable	In a preclinical study, ERAS-007 (ASN007) treatment inhibited proliferation and Erk signaling in a melanoma cell line harboring BRAF V600E in culture, and inhibited tumor growth in patient-derived xenograft (PDX) models, including a Zelboraf (vemurafenib)-resistant PDX model (PMID: 34337566).	34337566
BRAF V600E	colorectal cancer	sensitive	ERAS-007	Preclinical - Pdx & cell culture	Actionable	In a preclinical study, ERAS-007 (ASN007) treatment inhibited cell proliferation and Erk signaling in colorectal cancer cell lines harboring BRAF V600E in culture, and induced tumor regression in two patient-derived xenograft (PDX) models (PMID: 34337566).	34337566
NRAS G13D	mantle cell lymphoma	sensitive	ERAS-007	Preclinical - Cell line xenograft	Actionable	In a preclinical study, ERAS-007 (ASN007) treatment inhibited proliferation of a mantle cell lymphoma cell line harboring NRAS G13D in culture and inhibited tumor growth in xenograft models (PMID: 34337566).	34337566
NRAS Q61K	neuroblastoma	sensitive	ERAS-007	Preclinical - Cell line xenograft	Actionable	In a preclinical study, ERAS-007 (ASN007) treatment inhibited tumor growth in a neuroblastoma cell line xenograft model harboring NRAS Q61K (PMID: 34337566).	34337566
BRAF V600E	diffuse large B-cell lymphoma	sensitive	ERAS-007	Preclinical - Cell culture	Actionable	In a preclinical study, ERAS-007 (ASN007) treatment inhibited proliferation of diffuse large B-cell lymphoma cells harboring BRAF V600E in culture (PMID: 34337566).	34337566
HRAS G12V	urinary bladder cancer	sensitive	ERAS-007	Preclinical - Cell culture	Actionable	In a preclinical study, ERAS-007 (ASN007) treatment inhibited proliferation of a bladder cancer cell line harboring HRAS G12V in culture (PMID: 34337566).	34337566
NRAS Q61L	liver cancer	sensitive	ERAS-007	Preclinical - Cell culture	Actionable	In a preclinical study, ERAS-007 (ASN007) treatment inhibited proliferation of a liver cancer cell line harboring NRAS Q61L in culture (PMID: 34337566).	34337566
NRAS Q61R	melanoma	sensitive	ERAS-007	Preclinical - Cell culture	Actionable	In a preclinical study, ERAS-007 (ASN007) treatment inhibited proliferation of a melanoma cell line harboring NRAS Q61R in culture (PMID: 34337566).	34337566

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT04866134	Phase Ib/II	ERAS-007	A Study of ERAS-007 in Patients With Advanced or Metastatic Solid Tumors (HERKULES-1) (HERKULES-1)	Active, not recruiting	USA	0
NCT03415126	Phase I	ERAS-007	A Study of ASN007 in Patients With Advanced Solid Tumors	Completed	USA	0

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