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Therapy Detail

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Therapy Name CPI-613 + Hydroxychloroquine
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CPI-613 CPI613|CPI 613|Devimistat Devimistat (CPI-613) is an inhibitor of pyruvate dehydrogenase (PDH) and alpha-ketogluterate (KGDH), resulting in blockade of mitochondrial respiration which may lead to apoptosis and death of cancer cells (PMID: 29437791, PMID: 28495639, PMID: 32789692, PMID: 31512500).
Hydroxychloroquine Plaquenil HCQ Plaquenil (hydroxychloroquine sulfate) increases intralysosomal pH, resulting in inhibition of autophagic protein degradation and accumulation of autophagosomes, which potentially leads to cell death in autophagy-dependent tumor cells (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04593758 Phase Ib/II CPI-613 + Hydroxychloroquine To Evaluate Maximally Tolerated Dose (MTD), Safety and Efficacy of CPI-613 (Devimistat) Plus Hydroxychloroquine in Patients With Relapsed or Refractory Clear Cell Sarcoma of Soft Tissue Completed USA 0
NCT03929211 Phase Ib/II CPI-613 + Hydroxychloroquine CPI-613 and Hydroxychloroquine for Patients With High Risk Myelodysplastic Syndrome Withdrawn USA 0
NCT05733000 Phase II CPI-613 + Gemcitabine + Hydroxychloroquine CPI-613 + Hydroxychloroquine CPI-613 + Gemcitabine CPI-613 + Fluorouracil + Hydroxychloroquine CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors Recruiting USA 0


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