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Drug Name Hydroxychloroquine
Trade Name Plaquenil
Synonyms HCQ
Drug Descriptions

Plaquenil (hydroxychloroquine sulfate) increases intralysosomal pH, resulting in inhibition of autophagic protein degradation and accumulation of autophagosomes, which potentially leads to cell death in autophagy-dependent tumor cells (NCI Drug Dictionary).

DrugClasses
CAS Registry Number 118-42-3
NCIT ID C557

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Anastrozole + Hydroxychloroquine Abemaciclib Anastrozole Hydroxychloroquine 0 1
Abemaciclib + Fulvestrant + Hydroxychloroquine Abemaciclib Fulvestrant Hydroxychloroquine 0 1
Abemaciclib + Hydroxychloroquine Abemaciclib Hydroxychloroquine 0 2
Abemaciclib + Hydroxychloroquine + Letrozole Abemaciclib Hydroxychloroquine Letrozole 0 1
Atezolizumab + Cobimetinib + Hydroxychloroquine Atezolizumab Cobimetinib Hydroxychloroquine 0 1
Avelumab + Gemcitabine + Hydroxychloroquine + Nab-paclitaxel Avelumab Gemcitabine Hydroxychloroquine Nab-paclitaxel 0 1
Avelumab + Hydroxychloroquine + Palbociclib Avelumab Hydroxychloroquine Palbociclib 0 0
Axitinib + Hydroxychloroquine Axitinib Hydroxychloroquine 0 1
Bevacizumab + Carboplatin + Hydroxychloroquine + Paclitaxel Bevacizumab Carboplatin Hydroxychloroquine Paclitaxel 0 1
Bevacizumab + Fluorouracil + Hydroxychloroquine + Irinotecan + Leucovorin Bevacizumab Fluorouracil Hydroxychloroquine Irinotecan Leucovorin 0 1
Binimetinib + Hydroxychloroquine Binimetinib Hydroxychloroquine 0 2
Carboplatin + Hydroxychloroquine + Paclitaxel Carboplatin Hydroxychloroquine Paclitaxel 0 1
Cetuximab + Encorafenib + Hydroxychloroquine Cetuximab Encorafenib Hydroxychloroquine 0 1
CPI-613 + Fluorouracil + Hydroxychloroquine CPI-613 Fluorouracil Hydroxychloroquine 0 1
CPI-613 + Gemcitabine + Hydroxychloroquine CPI-613 Gemcitabine Hydroxychloroquine 0 1
CPI-613 + Hydroxychloroquine CPI-613 Hydroxychloroquine 0 3
Cyclophosphamide + Dexamethasone + Hydroxychloroquine + Sirolimus Cyclophosphamide Dexamethasone Hydroxychloroquine Sirolimus 0 1
Dabrafenib + Hydroxychloroquine + Trametinib Dabrafenib Hydroxychloroquine Trametinib 1 4
Dasatinib + Hydroxychloroquine + Metformin + Nelfinavir + Sirolimus Dasatinib Hydroxychloroquine Metformin Nelfinavir Sirolimus 0 1
Dasatinib + Hydroxychloroquine + Metformin + Sirolimus Dasatinib Hydroxychloroquine Metformin Sirolimus 0 1
Encorafenib + Hydroxychloroquine + Panitumumab Encorafenib Hydroxychloroquine Panitumumab 0 1
Entinostat + Hydroxychloroquine + Regorafenib Entinostat Hydroxychloroquine Regorafenib 0 1
Everolimus + Hydroxychloroquine Everolimus Hydroxychloroquine 0 2
Gedatolisib + Hydroxychloroquine Gedatolisib Hydroxychloroquine 0 1
Gemcitabine + Hydroxychloroquine + Ipilimumab Gemcitabine Hydroxychloroquine Ipilimumab 0 0
Gemcitabine + Hydroxychloroquine + Ipilimumab + Nab-paclitaxel Gemcitabine Hydroxychloroquine Ipilimumab Nab-paclitaxel 0 1
Gemcitabine + Hydroxychloroquine + Nab-paclitaxel Gemcitabine Hydroxychloroquine Nab-paclitaxel 0 1
Hydroxychloroquine Hydroxychloroquine 0 9
Hydroxychloroquine + Ipilimumab Hydroxychloroquine Ipilimumab 0 0
Hydroxychloroquine + Ipilimumab + Nab-paclitaxel Hydroxychloroquine Ipilimumab Nab-paclitaxel 0 0
Hydroxychloroquine + Ipilimumab + Nivolumab Hydroxychloroquine Ipilimumab Nivolumab 0 1
Hydroxychloroquine + Itraconazole Hydroxychloroquine Itraconazole 0 1
Hydroxychloroquine + Letrozole + Palbociclib Hydroxychloroquine Letrozole Palbociclib 0 1
Hydroxychloroquine + LY3214996 Hydroxychloroquine LY3214996 0 1
Hydroxychloroquine + Metformin + Nelfinavir + Sirolimus Hydroxychloroquine Metformin Nelfinavir Sirolimus 0 1
Hydroxychloroquine + Metformin + Sirolimus Hydroxychloroquine Metformin Sirolimus 0 1
Hydroxychloroquine + MK2206 Hydroxychloroquine MK2206 0 1
Hydroxychloroquine + Nivolumab Hydroxychloroquine Nivolumab 0 1
Hydroxychloroquine + Palbociclib Hydroxychloroquine Palbociclib 0 1
Hydroxychloroquine + Sirolimus Hydroxychloroquine Sirolimus 0 1
Hydroxychloroquine + Sorafenib Hydroxychloroquine Sorafenib 0 2
Hydroxychloroquine + Temsirolimus Hydroxychloroquine Temsirolimus 0 1
Hydroxychloroquine + Trametinib Hydroxychloroquine Trametinib 0 5
Hydroxychloroquine + Ulixertinib Hydroxychloroquine Ulixertinib 0 2
Hydroxychloroquine + Vemurafenib Hydroxychloroquine Vemurafenib 0 1
Hydroxychloroquine + Vorinostat Hydroxychloroquine Vorinostat 0 2


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