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Therapy Name	Ropeginterferon
Synonyms
Therapy Description	Ropeginterferon is polyethylene glycol (PEG)-conjugated recombinant interferon alpha, subtype 2b, which may result in reduced tumor cell proliferation and colony growth (PMID: 30287855).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Ropeginterferon		RopegInterferon alpha-2b\|Ropeg\|Besremi		Ropeginterferon is polyethylene glycol (PEG)-conjugated recombinant interferon alpha, subtype 2b, which may result in reduced tumor cell proliferation and colony growth (PMID: 30287855).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
JAK2 V617F	polycythemia vera	sensitive	Ropeginterferon	Clinical Study - Cohort	Actionable	In a clinical study using data from a Phase III trial, polycythemia vera patients demonstrated significant reduction in the median JAK2 V617F mutational burden at 12 months following treatment with Ropeginterferon compared to Droxia (hydroxyurea) (13.8% vs. 33.2%; p<0.02) (PMID: 30287855; NCT01949805).	30287855
JAK2 V617F	polycythemia vera	sensitive	Ropeginterferon	Preclinical - Patient cell culture	Actionable	In a preclinical study, patient-derived erythroid progenitors harboring JAK2 V617F demonstrated sensitivity to Ropeginterferon in culture (PMID: 30287855).	30287855
JAK2 V617F	myeloproliferative neoplasm	sensitive	Ropeginterferon	Preclinical - Cell culture	Actionable	In a preclinical study, Ropeginterferon treatment resulted in dose-dependent inhibition of cell proliferation in myeloproliferative neoplasm cell lines harboring JAK2 V617F in culture (PMID: 30287855).	30287855
JAK2 V617F	acute megakaryocytic leukemia	sensitive	Ropeginterferon	Preclinical - Cell culture	Actionable	In a preclinical study, a megakaryoblastic leukemia cell line expressing JAK2 V617F demonstrated inhibition of cell proliferation in culture when treated with Ropeginterferon (PMID: 30287855).	30287855

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT05481151	Phase III	Ropeginterferon	A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV	Active, not recruiting	USA \| CAN	0

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