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Drug Name | Tozasertib |
Trade Name | |
Synonyms | MK-0457|VX-680 |
Drug Descriptions |
Tozasertib (VX-680) is a pan-AURK inhibitor with increased potency against Aurora kinase A (AURKA), and has additional activity against BCR-ABL, potentially resulting in decreased tumor growth (PMID: 14981513, PMID: 22772060, PMID: 32017040). |
DrugClasses | AURK Inhibitor (Pan) 12 BCR-ABL Inhibitor 32 |
CAS Registry Number | 899827-04-4 |
NCIT ID | C61319 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
BIRB-796 + Tozasertib | BIRB-796 Tozasertib | 0 | 0 |
Doxorubicin + Tozasertib | Doxorubicin Tozasertib | 0 | 0 |
Palbociclib + Tozasertib | Palbociclib Tozasertib | 0 | 0 |
Tozasertib | Tozasertib | 3 | 0 |
Tozasertib + Venetoclax | Tozasertib Venetoclax | 0 | 0 |
Tozasertib + Vorinostat | Tozasertib Vorinostat | 0 | 0 |