Tozasertib
Drug Detail
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| Drug Name | Tozasertib |
| Trade Name | |
| Synonyms | MK-0457|VX-680 |
| Drug Descriptions |
Tozasertib (VX-680) is a pan-AURK inhibitor with increased potency against Aurora kinase A (AURKA), and has additional activity against BCR-ABL, potentially resulting in decreased tumor growth (PMID: 14981513, PMID: 22772060, PMID: 32017040). |
| DrugClasses | AURK Inhibitor (Pan) 12 BCR-ABL Inhibitor 32 |
| CAS Registry Number | 899827-04-4 |
| NCIT ID | C61319 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| BIRB-796 + Tozasertib | BIRB-796 Tozasertib | 0 | 0 |
| Doxorubicin + Tozasertib | Doxorubicin Tozasertib | 0 | 0 |
| Palbociclib + Tozasertib | Palbociclib Tozasertib | 0 | 0 |
| Tozasertib | Tozasertib | 3 | 0 |
| Tozasertib + Venetoclax | Tozasertib Venetoclax | 0 | 0 |
| Tozasertib + Vorinostat | Tozasertib Vorinostat | 0 | 0 |
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