basal cell carcinoma
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ID DOID:2513
Name basal cell carcinoma
Definition A skin carcinoma affecting basal cells.
Source DiseaseOntology.org
Alt Ids DOID:4275 DOID:4276
Path disease disease of cellular proliferation cancer organ system cancer integumentary system cancer skin cancer skin carcinoma basal cell carcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600E Dabrafenib + Trametinib basal cell carcinoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01367665 Phase II Vismodegib STEVIE: A Study of Vismodegib in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma Completed TUR | SWE | SVN | SVK | ROU | POL | NZL | NOR | NLD | LTU | ITA | ISR | IRL | HUN | HRV | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CHE | CAN | BRA | BGR | BEL | AUT | AUS | ARG 6
NCT01543581 Phase II Vismodegib Vismodegib for Treatment of Basal Cell Carcinoma (Erivedge) Completed 0
NCT01700049 Phase II Vismodegib Study Evaluating the Efficacy of Oral Vismodegib in Various Histologic Subtypes Completed USA 0
NCT01815840 Phase II Vismodegib A Study of Two Vismodegib Regimens in Patients With Multiple Basal Cell Carcinomas Completed USA | NLD | ITA | FRA | ESP | DEU | CAN | AUT 2
NCT01898598 Phase II Vismodegib A Study of Vismodegib With Surgery in Patients With Previously Untreated Basal Cell Carcinoma Terminated USA 0
NCT02067104 Phase II Vismodegib Vismodegib in Basal Cell Carcinomas (BCC) Chemoprevention Terminated USA 0
NCT02120677 Phase I Itraconazole Topical Itraconazole in the Treatment of Basal Cell Carcinoma Completed USA 0
NCT02303041 Phase I Buparlisib + Sonidegib Erismodegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma Terminated USA 0
NCT02436408 FDA approved Vismodegib VISmodegib for ORbital and Periocular Basal Cell Carcinoma Completed USA 0
NCT02639117 Phase I Vismodegib Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas Completed USA 0
NCT02690948 Phase II Pembrolizumab + Vismodegib Pembrolizumab Pembrolizumab With or Without Vismodegib in Treating Metastatic or Unresectable Basal Cell Skin Cancer Completed USA 0
NCT02699723 Phase I Arsenic trioxide + Itraconazole Arsenic Trioxide and Itraconazole in Treating Patients With Advanced Basal Cell Cancer Withdrawn 0
NCT02735356 Phase I Itraconazole Topical Itraconazole in Treating Patients With Basal Cell Cancer Completed USA 0
NCT02978625 Phase II Nivolumab + Talimogene laherparepvec Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Active, not recruiting USA 0
NCT03132636 Phase II Cemiplimab PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy Completed USA | ITA | GRC | FRA | ESP | DEU | CHE | CAN | BEL | AUT 0
NCT03220347 Phase I CC-90010 A Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of CC-90010 in Subjects With Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin's Lymphomas Terminated ITA | FRA | ESP 1
NCT03517488 Phase I XmAb20717 A Study of XmAb20717 in Subjects With Selected Advanced Solid Tumors (DUET-2) Completed USA 0
NCT03521830 Phase II Nivolumab Ipilimumab + Nivolumab Nivolumab Alone or Plus Ipilimumab for Patients With Locally-Advanced Unresectable or Metastatic Basal Cell Carcinoma Recruiting USA 0
NCT03534947 Phase II Imiquimod + Sonidegib Sonidegib A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma (SONIB) Recruiting AUS 0
NCT03610022 FDA approved Vismodegib Relationship Between Pharmacokinetics and Safety of Vismodegib - OPTIVISMO-1 (OPTIVISMO-1) Completed FRA 0
NCT03767348 Phase Ib/II Nivolumab + RP1 RP1 Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE) Recruiting USA | GBR | FRA | ESP | DEU 0
NCT03816332 Phase I Ipilimumab + Nivolumab + Prednisone + Tacrolimus Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers Active, not recruiting USA 0
NCT03897036 Phase I Silmitasertib Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC) Completed USA 0
NCT04089527 Phase I FT-1101 Study to Evaluate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic of CC-95775 in Subjects With Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma Completed FRA | ESP 0
NCT04155190 Phase II Patidegib topical gel An Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas in Patients With Non-Gorlin High Frequency BCC Terminated USA 0
NCT04323202 Phase I Pembrolizumab Neoadjuvant-Adjuvant Pembrolizumab in Resectable Advanced Basal Cell Carcinoma of H&N Completed USA 0
NCT04349436 Phase Ib/II RP1 A Phase 1B/2 Study of RP1 in Solid Organ Transplant Patients With Advanced Cutaneous Malignancies (ARTACUS) Recruiting USA 0
NCT04362722 Phase II Daromun Intratumoral Administration of Daromun in Non-melanoma Skin Cancer Patients (DUNCAN) Unknown status POL | DEU | CHE 0
NCT04416516 Phase II ASN002 Safety and Efficacy of ASN-002 Combined With a Hedgehog Pathway Inhibitor Completed AUS 0
NCT04669808 Phase II Cotsiranib Open Label, Dose Escalation Study for the Safety and Efficacy of STP705 in Adult Patients With Basal Cell Carcinoma Completed USA 0
NCT04806646 Phase II Sonidegib Tailored Sonidegib Schedule After Complete Response in BCC (SONIBEC) Recruiting ITA 0
NCT04925713 Phase I IFx-Hu2.0 IFx-Hu2.0 for the Treatment of Patients With Skin Cancer Completed USA 0
NCT05086692 Phase Ib/II MDNA11 + Pembrolizumab A Beta-only IL-2 ImmunoTherapY Study (ABILITY-1) Recruiting USA | IRL | ESP | CAN | AUS 2
NCT05188729 Phase II LTX-315 Open-Label Proof of Concept Study of LTX-315 in Basal Cell Carcinoma Completed USA 0
NCT05329792 Phase II Daromun L19IL2/L19TNF in Skin Cancer Patients Unknown status ITA | FRA | ESP 0
NCT05378425 Phase I NTX-1088 NTX-1088 + Pembrolizumab A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab Recruiting USA | POL | ISR 0
NCT05533697 Phase Ib/II Ipilimumab + mRNA-4359 + Nivolumab mRNA-4359 + Pembrolizumab mRNA-4359 Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors Recruiting USA | GBR | ESP | AUS 0
NCT05561634 Phase II Vismodegib Radiotherapy by Sonic Hedgehog Pathway Inhibitors in Basal Cell Carcinoma (RADIOSONIC) Recruiting FRA 0
NCT05651828 Phase I Vismodegib Adaptive Therapy of Vismodegib in Advanced Basal Cell Carcinoma Recruiting USA 0
NCT05713760 Phase II KX2-391 Proof of Concept Study to Access Superficial Basal Cell Carcinoma in Adults Completed USA 0
NCT05859074 Phase I MQ710 + Pembrolizumab MQ710 A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer Recruiting USA 0
NCT05896839 Phase Ib/II Ipilimumab + Nivolumab + Prednisone + Sirolimus Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer Recruiting USA 0
NCT05929664 Phase II Cemiplimab Cemiplimab for the Treatment of Locally Advanced Head and Neck Basal Cell Carcinoma Before Surgery Recruiting USA 0
NCT06112522 Phase II KX2-391 Tirbanubulin (Klisiry) in the Treatment of Basal Cell Carcinoma Recruiting FRA 0
NCT06344052 Phase II Vismodegib SP-002 + Vismodegib To Assess the Safety and Efficacy of SP-002 With Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma Recruiting USA 0
NCT06409195 Phase II SM-020 A Trial to Study the Safety and Efficacy of SM-020 Gel 1.0% in Subjects With Seborrheic Keratoses and Non-Melanoma Skin Cancers Recruiting USA 0
NCT06422936 Phase II BO-112 Clinical Trial to Evaluate BO-112 in Patients With Basal Cell Carcinoma (BCC) (SPOTLIGHT204) Recruiting ISR | ESP 0
NCT06514651 Phase I MAQ-001 Ipilimumab + MAQ-001 MAQ-001 in Patients With Advanced Solid Tumors Recruiting FRA 0
NCT06624475 Phase II Nivolumab and relatlimab-rmbw Nivolumab Neoadjuvant Opdualag Versus Nivolumab for Resectable High-Risk Basal Cell Carcinoma Recruiting USA 0
NCT06981325 Phase II Cemiplimab Evaluation of Efficacy and Safety of Cemiplimab as First Line Treatment for Advanced Basal Cell Carcinoma (BCC) Patients (CEMI-first) Recruiting DEU 0
NCT07010692 Phase Ib/II KX2-391 Treating Basal and Squamous Cell Carcinomas With Fractional Laser and Tirbanibulin Ointment Recruiting USA 0