brain ependymoma
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ID DOID:7497
Name brain ependymoma
Definition A brain glioma that is characterized by tumor of the ependyma, has_material_basis_in abnormally proliferating cells derives_from ependymal cells, located_in spine in adults and located_in intracranial (4th ventricle) in children.
Source DiseaseOntology.org
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SNOMEDCT_US_2023_03_01:254939008
Path disease disease of cellular proliferation cancer organ system cancer nervous system cancer central nervous system cancer brain cancer brain glioma brain ependymoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01096368 Phase III Carboplatin + Cyclophosphamide + Vincristine sulfate liposome Carboplatin + Etoposide + Vincristine sulfate liposome Cisplatin + Cyclophosphamide + Etoposide Cisplatin + Cyclophosphamide + Etoposide + Vincristine sulfate liposome Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Active, not recruiting USA | NZL | CAN | AUS 0
NCT01295944 Phase II Bevacizumab + Carboplatin Carboplatin and Bevacizumab for Recurrent Ependymoma Completed USA 0
NCT02458339 Phase I Methotrexate Methotrexate Infusion Into Fourth Ventricle in Children With Recurrent Malignant Fourth Ventricular Brain Tumors Completed USA 0
NCT03434262 Phase I Ribociclib + Trametinib Filgrastim + Gemcitabine + Ribociclib Ribociclib + Sonidegib SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Completed USA 0
NCT03698994 Phase II Ulixertinib Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) Active, not recruiting USA 1
NCT03727841 Phase II Marizomib Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial, and Spinal Cord Ependymoma Terminated USA 0
NCT03838042 Phase Ib/II Entinostat + Nivolumab INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies (INFORM2 NivEnt) Recruiting SWE | NLD | FRA | DEU | CHE | AUT | AUS 0
NCT04732065 Phase I ONC206 ONC206 for Treatment of Newly Diagnosed or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant Brain Tumors (PNOC 023) Recruiting USA | CHE 0
NCT04903080 Phase I HER2 CAR-T cells HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma Active, not recruiting USA | CAN 0
NCT04958486 Phase I Azacitidine + Trastuzumab Combination Intraventricular Chemotherapy Pilot Study: 5-Azacytidine (5-AZA) and Trastuzumab Infusions Into the Fourth Ventricle or Resection Cavity in Children and Adults With Recurrent or Residual Posterior Fossa Ependymoma Completed USA 0
NCT05106296 Phase I Ibrutinib + Indoximod + Temozolomide Cyclophosphamide + Etoposide + Ibrutinib + Indoximod Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer Recruiting USA 0
NCT05169944 Phase I Magrolimab Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors (PNOC025) Completed USA 0
NCT05887882 Phase I TGF-beta-imprinted NK cells Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors (PNOC028) Recruiting USA 0
NCT07017816 Phase I Nivolumab + SGT-53 A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. (JACOB) Not yet recruiting USA 0