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Drug Name | ART0380 |
Trade Name | |
Synonyms | ART-0380|ART 0380 |
Drug Descriptions |
ART0380 inhibits ATR activity leading to decreased phopshorylation of Chk1, which may result in impaired DNA damage repair, induction of apoptosis in tumor cells, and antitumor activity (NCI Drug Dictionary, (Ann Oncol 34 (2023): S475-S476). |
DrugClasses | ATR Inhibitor 16 |
CAS Registry Number | NA |
NCIT ID | C179292 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
ART0380 | ART0380 | 5 | 2 |
ART0380 + Gemcitabine | ART0380 Gemcitabine | 0 | 1 |