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Drug Name | PF-07284892 |
Trade Name | |
Synonyms | PF 07284892|PF07284892|ARRY-558|ARRY 558|ARRY558 |
Drug Descriptions |
PF-07284892 is a small molecule inhibitor of SHP2 that may block MAPK signaling and lead to tumor growth inhibition (PMID: 37269335). |
DrugClasses | SHP2 Inhibitor 20 |
CAS Registry Number | NA |
NCIT ID | C178469 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Binimetinib + Encorafenib + PF-07284892 | Binimetinib Encorafenib PF-07284892 | 1 | 0 |
Binimetinib + PF-07284892 | Binimetinib PF-07284892 | 0 | 1 |
Cetuximab + Encorafenib + PF-07284892 | Cetuximab Encorafenib PF-07284892 | 1 | 1 |
Lorlatinib + PF-07284892 | Lorlatinib PF-07284892 | 2 | 1 |
PF-07284892 | PF-07284892 | 0 | 1 |