PF-07284892
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| Drug Name | PF-07284892 |
| Trade Name | |
| Synonyms | PF 07284892|PF07284892|ARRY-558|ARRY 558|ARRY558 |
| Drug Descriptions |
PF-07284892 is a small molecule inhibitor of SHP2 that may block MAPK signaling and lead to tumor growth inhibition (PMID: 37269335). |
| DrugClasses | SHP2 Inhibitor 20 |
| CAS Registry Number | NA |
| NCIT ID | C178469 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Binimetinib + Encorafenib + PF-07284892 | Binimetinib Encorafenib PF-07284892 | 1 | 0 |
| Binimetinib + PF-07284892 | Binimetinib PF-07284892 | 0 | 1 |
| Cetuximab + Encorafenib + PF-07284892 | Cetuximab Encorafenib PF-07284892 | 1 | 1 |
| Lorlatinib + PF-07284892 | Lorlatinib PF-07284892 | 2 | 1 |
| PF-07284892 | PF-07284892 | 0 | 1 |
| PF-07284892 + PF-07985045 | PF-07284892 PF-07985045 | 0 | 1 |
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