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Drug Name | Lorlatinib |
Trade Name | Lorbrena |
Synonyms | PF-06463922|Lorviqua |
Drug Descriptions |
Lorbrena (lorlatinib) is a small molecule inhibitor of Alk and Ros1 fusion proteins, which may result in suppression of Alk and Ros1-mediated signaling thereby inhibiting cell growth and causing tumor regression (PMID: 26144315). Lorbrena (lorlatinib) is FDA approved for use in patients with ALK-positive non-small cell lung cancer (FDA.gov). |
DrugClasses | ALK Inhibitor 32 ROS1 Inhibitor 20 |
CAS Registry Number | 1454846-35-5 |
NCIT ID | C113655 |