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Drug Name Lorlatinib
Trade Name Lorbrena
Synonyms PF-06463922|Lorviqua
Drug Descriptions

Lorbrena (lorlatinib) is a small molecule inhibitor of Alk and Ros1 fusion proteins, which may result in suppression of Alk and Ros1-mediated signaling thereby inhibiting cell growth and causing tumor regression (PMID: 26144315). Lorbrena (lorlatinib) is FDA approved for use in patients with ALK-positive non-small cell lung cancer (FDA.gov).

DrugClasses ALK Inhibitor 32 ROS1 Inhibitor 20
CAS Registry Number 1454846-35-5
NCIT ID C113655

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Therapy Name Drugs Efficacy Evidence Clinical Trials
4SC-205 + Lorlatinib 4SC-205 Lorlatinib 1 0
Afatinib + Lorlatinib Afatinib Lorlatinib 1 0
Avelumab + Lorlatinib Avelumab Lorlatinib 0 0
Bevacizumab + Lorlatinib Bevacizumab Lorlatinib 3 0
Binimetinib + Lorlatinib Binimetinib Lorlatinib 0 1
Cabozantinib + Lorlatinib Cabozantinib Lorlatinib 0 0
Capmatinib + Lorlatinib Capmatinib Lorlatinib 0 0
Carboplatin + Cyclophosphamide + Etoposide + Lorlatinib + Methotrexate + Vincristine Sulfate Carboplatin Cyclophosphamide Etoposide Lorlatinib Methotrexate Vincristine Sulfate 0 1
Carboplatin + Lorlatinib Carboplatin Lorlatinib 0 1
Carboplatin + Lorlatinib + Pemetrexed Disodium Carboplatin Lorlatinib Pemetrexed Disodium 0 2
Cisplatin + Cyclophosphamide + Lorlatinib + Vincristine Sulfate Cisplatin Cyclophosphamide Lorlatinib Vincristine Sulfate 0 1
Cisplatin + Lorlatinib Cisplatin Lorlatinib 0 1
Cisplatin + Lorlatinib + Pemetrexed Disodium Cisplatin Lorlatinib Pemetrexed Disodium 0 2
Crizotinib + Lorlatinib Crizotinib Lorlatinib 0 1
Cyclophosphamide + Doxorubicin + Lorlatinib + Vincristine Sulfate Cyclophosphamide Doxorubicin Lorlatinib Vincristine Sulfate 3 0
Cyclophosphamide + Lorlatinib + Topotecan Cyclophosphamide Lorlatinib Topotecan 1 1
Dasatinib + Lorlatinib Dasatinib Lorlatinib 0 0
Everolimus + Lorlatinib Everolimus Lorlatinib 0 0
Idasanutlin + Lorlatinib Idasanutlin Lorlatinib 2 0
Lorlatinib Lorlatinib 284 17
Lorlatinib + Olaparib Lorlatinib Olaparib 0 0
Lorlatinib + Osimertinib Lorlatinib Osimertinib 0 0
Lorlatinib + Pemetrexed Disodium Lorlatinib Pemetrexed Disodium 0 1
Lorlatinib + PF-07284892 Lorlatinib PF-07284892 2 1
Lorlatinib + Ponatinib Lorlatinib Ponatinib 0 0
Lorlatinib + Ramucirumab Lorlatinib Ramucirumab 0 1
Lorlatinib + Saracatinib Lorlatinib Saracatinib 2 0
Lorlatinib + Savolitinib Lorlatinib Savolitinib 0 0
Lorlatinib + Selumetinib Lorlatinib Selumetinib 0 0
Lorlatinib + SHP099 Lorlatinib SHP099 2 0
Lorlatinib + Temozolomide Lorlatinib Temozolomide 0 1
Lorlatinib + TNO155 Lorlatinib TNO155 2 0
Lorlatinib + Trametinib Lorlatinib Trametinib 0 0
Lorlatinib + Vistusertib Lorlatinib Vistusertib 0 0


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