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Drug Name | HX008 |
Trade Name | |
Synonyms | HX-008|HX 008|Pucotenlimab |
Drug Descriptions |
HX008 is a monoclonal antibody that binds to PD-1 (PDCD1) and blocks its interaction with PD-L1 (CD274) and PD-L2 (PDCD1LG2), inhibiting downstream signaling and potentially leading to activation of T-cell-mediated immune response against tumor cells and inhibition of tumor growth (PMID: 32106752). |
DrugClasses | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 |
CAS Registry Number | NA |
NCIT ID | C160717 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Capecitabine + HX008 + Oxaliplatin | Capecitabine HX008 Oxaliplatin | 0 | 0 |
Cisplatin + Gemcitabine + HX008 | Cisplatin Gemcitabine HX008 | 0 | 0 |
HX008 | HX008 | 0 | 0 |
HX008 + Irinotecan | HX008 Irinotecan | 0 | 0 |
HX008 + MRG003 | HX008 MRG003 | 0 | 0 |
HX008 + OH2 | HX008 OH2 | 0 | 0 |