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Drug Name Asparaginase
Trade Name Elspar
Synonyms L-asparaginase|ASP-1
Drug Descriptions

Elspar (asparaginase) is an enzyme that converts L-asparagine to L-aspartic acid and ammonia, reducing the available L-asparagine, which may result in cell-cycle arrest and apoptosis in leukemia cells (NCI Drug Dictionary).

DrugClasses
CAS Registry Number 9015-68-3
NCIT ID C286

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Asparaginase Asparaginase 0 5
Asparaginase + Cyclophosphamide + Cytarabine + Dasatinib + Daunorubicin + Mercaptopurine + Methotrexate + Prednisone + Vincristine Sulfate Asparaginase Cyclophosphamide Cytarabine Dasatinib Daunorubicin Mercaptopurine Methotrexate Prednisone Vincristine Sulfate 0 1
Asparaginase + Cyclophosphamide + Cytarabine + Dasatinib + Dexamethasone + Doxorubicin + Methotrexate + Thioguanine + Vincristine Sulfate Asparaginase Cyclophosphamide Cytarabine Dasatinib Dexamethasone Doxorubicin Methotrexate Thioguanine Vincristine Sulfate 0 1
Asparaginase + Cyclophosphamide + Cytarabine + Daunorubicin + Mercaptopurine + Methotrexate + Prednisone + Vincristine Sulfate Asparaginase Cyclophosphamide Cytarabine Daunorubicin Mercaptopurine Methotrexate Prednisone Vincristine Sulfate 0 1
Asparaginase + Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Thioguanine + Vincristine Sulfate Asparaginase Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Thioguanine Vincristine Sulfate 0 1
Asparaginase + Cyclophosphamide + Cytarabine + Dexamethasone + Imatinib + Methotrexate + Vincristine Sulfate Asparaginase Cyclophosphamide Cytarabine Dexamethasone Imatinib Methotrexate Vincristine Sulfate 0 0
Asparaginase + Cyclophosphamide + Etoposide Asparaginase Cyclophosphamide Etoposide 0 1
Asparaginase + Cytarabine Asparaginase Cytarabine 0 2
Asparaginase + Dasatinib + Daunorubicin + Prednisone + Vincristine Sulfate Asparaginase Dasatinib Daunorubicin Prednisone Vincristine Sulfate 0 0
Asparaginase + Dexamethasone + DT2216 + Vincristine Sulfate Asparaginase DT2216 Dexamethasone Vincristine Sulfate 0 0
Asparaginase + Dexamethasone + Mitoxantrone + Vincristine Sulfate Asparaginase Dexamethasone Mitoxantrone Vincristine Sulfate 0 1
Asparaginase + Ribociclib Asparaginase Ribociclib 0 0


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