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Drug Name | Alvocidib |
Trade Name | |
Synonyms | flavopiridol|HMR 1275|L-868275|DSP-2033 |
Drug Descriptions |
Alvocidib (flavopiridol) is an inhibitor of CDK1, CDK2, CDK4, CDK6, CDK7, and CDK9, which may induce cell cycle arrest and apoptosis in cancer cells (PMID: 12165651, PMID: 8674031, PMID: 24470357). |
DrugClasses | CDK Inhibitor (Pan) 3 CDK1 Inhibitor 13 CDK2 Inhibitor 31 CDK4 Inhibitor 17 CDK6 Inhibitor 6 CDK7 Inhibitor 16 CDK9 Inhibitor 21 |
CAS Registry Number | 131740-09-5 |
NCIT ID | C1571 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Aldoxorubicin + Alvocidib | Aldoxorubicin Alvocidib | 0 | 0 |
Alvocidib | Alvocidib | 3 | 2 |
Alvocidib + BAY-293 | Alvocidib BAY-293 | 0 | 0 |
Alvocidib + Crizotinib | Alvocidib Crizotinib | 1 | 0 |
Alvocidib + Cytarabine | Alvocidib Cytarabine | 0 | 1 |
Alvocidib + Cytarabine + Daunorubicin | Alvocidib Cytarabine Daunorubicin | 0 | 1 |
Alvocidib + Decitabine + Venetoclax | Alvocidib Decitabine Venetoclax | 0 | 1 |
Alvocidib + Doxorubicin | Alvocidib Doxorubicin | 0 | 0 |
Alvocidib + Palbociclib | Alvocidib Palbociclib | 0 | 0 |
Alvocidib + Seliciclib | Alvocidib Seliciclib | 0 | 0 |
Alvocidib + Sorafenib | Alvocidib Sorafenib | 0 | 0 |
Alvocidib + Venetoclax | Alvocidib Venetoclax | 0 | 1 |