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Drug Name | XL888 |
Trade Name | |
Synonyms | XL-888 |
Drug Descriptions |
XL888 inhibits HSP90, resulting in degradation of HSP90 client proteins, and potentially leading to decreased tumor growth (PMID: 23538902, PMID: 22877636, PMID: 29674508). |
DrugClasses | HSP90 Inhibitor 35 |
CAS Registry Number | 1149705-71-4 |
NCIT ID | C79835 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cobimetinib + Vemurafenib + XL888 | Cobimetinib Vemurafenib XL888 | 0 | 1 |
Pembrolizumab + XL888 | Pembrolizumab XL888 | 0 | 1 |
Vemurafenib + XL888 | Vemurafenib XL888 | 1 | 1 |
XL888 | XL888 | 1 | 0 |