Poziotinib
Drug Detail
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| Drug Name | Poziotinib |
| Trade Name | |
| Synonyms | HM781-36B|NOV120101 |
| Drug Descriptions |
Poziotinib (HM781-36B) is a pan-ErbB inhibitor that inhibits EGFR, ERBB2 (HER2) and ERBB4 (HER4), thereby reducing proliferation of tumor cells that overexpress these receptors (PMID: 21306821, PMID: 31588020). |
| DrugClasses | EGFR Inhibitor (Pan) 63 HER inhibitor (Pan) 6 |
| CAS Registry Number | 1092364-38-9 |
| NCIT ID | C98838 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Ado-trastuzumab emtansine + Poziotinib | Ado-trastuzumab emtansine Poziotinib | 0 | 1 |
| Capmatinib + Poziotinib | Capmatinib Poziotinib | 0 | 0 |
| Fulvestrant + Poziotinib | Fulvestrant Poziotinib | 0 | 0 |
| Poziotinib | Poziotinib | 0 | 7 |
| Poziotinib + Tepotinib | Poziotinib Tepotinib | 0 | 0 |
| Poziotinib + TNO155 | Poziotinib TNO155 | 0 | 0 |
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