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Drug Name | Tepotinib |
Trade Name | Tepmetko |
Synonyms | EMD1214063|EMD-1214063|EMD 1214063|MSC2156119|MSC-2156119|MSC2156119J |
Drug Descriptions |
Tepmetko (tepotinib) selectively binds to the proto-oncogene hepatocyte growth factor receptor (HGFR or c-Met), which inhibits c-Met phosphorylation and disrupts c-Met-mediated signaling pathways, thereby suppressing tumor growth in tumor cells with activated or overexpression of c-Met protein (PMID: 32328660). Tepmetko (tepotinib) is FDA approved for use in patients with metastatic non-small cell lung cancer harboring MET exon 14 skipping mutations (FDA.gov). |
DrugClasses | MET Inhibitor 59 |
CAS Registry Number | 1100598-32-0 |
NCIT ID | C88314 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Amivantamab-vmjw + Tepotinib | Amivantamab-vmjw Tepotinib | 0 | 1 |
Cetuximab + Tepotinib | Cetuximab Tepotinib | 0 | 1 |
Entrectinib + Tepotinib | Entrectinib Tepotinib | 0 | 0 |
Erlotinib + Tepotinib | Erlotinib Tepotinib | 0 | 0 |
Gefitinib + Tepotinib | Gefitinib Tepotinib | 0 | 0 |
Infigratinib + Tepotinib | Infigratinib Tepotinib | 0 | 0 |
Osimertinib + Tepotinib | Osimertinib Tepotinib | 0 | 2 |
Pembrolizumab + Tepotinib | Pembrolizumab Tepotinib | 0 | 1 |
Poziotinib + Tepotinib | Poziotinib Tepotinib | 0 | 0 |
Radiotherapy + Tepotinib | Radiotherapy Tepotinib | 0 | 0 |
Ramucirumab + Tepotinib | Ramucirumab Tepotinib | 0 | 1 |
Sotorasib + Tepotinib | Sotorasib Tepotinib | 0 | 0 |
Tepotinib | Tepotinib | 0 | 7 |