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Drug Name Dactolisib
Trade Name
Synonyms NVP-BEZ235|BEZ235
Drug Descriptions

Dactolisib (BEZ235) inhibits PI3K kinase, mTOR kinase, and ATR, which may result in tumor cell apoptosis and growth inhibition of tumor cells (PMID: 18606717, PMID: 21552262, PMID: 32088816).

DrugClasses ATR Inhibitor 16 mTOR Inhibitor 51 PI3K Inhibitor (Pan) 42
CAS Registry Number 915019-65-7
NCIT ID C74072

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Dactolisib Abiraterone Dactolisib 0 0
ABT-737 + Dactolisib ABT-737 Dactolisib 1 0
ABT-737 + Dactolisib + Trametinib ABT-737 Dactolisib Trametinib 0 0
Aldoxorubicin + Dactolisib Aldoxorubicin Dactolisib 0 0
Binimetinib + Dactolisib Binimetinib Dactolisib 1 0
Dactolisib Dactolisib 28 0
Dactolisib + Docetaxel Dactolisib Docetaxel 0 0
Dactolisib + Doxorubicin Dactolisib Doxorubicin 0 0
Dactolisib + Everolimus Dactolisib Everolimus 0 1
Dactolisib + Palbociclib Dactolisib Palbociclib 0 0
Dactolisib + PD-0325901 Dactolisib PD-0325901 0 0
Dactolisib + PD98059 Dactolisib PD98059 0 0
Dactolisib + Pimasertib Dactolisib Pimasertib 0 0
Dactolisib + PU-H71 Dactolisib PU-H71 0 0
Dactolisib + Ruxolitinib Dactolisib Ruxolitinib 2 0
Dactolisib + Selumetinib Dactolisib Selumetinib 2 0
Dactolisib + Sorafenib Dactolisib Sorafenib 1 0
Dactolisib + U0126 Dactolisib U0126 0 0
Dactolisib + unspecified CTLA4 antibody + unspecified PD-1 antibody Dactolisib unspecified CTLA4 antibody unspecified PD-1 antibody 0 0
Dactolisib + Vemurafenib Dactolisib Vemurafenib 1 0
Dactolisib + Venetoclax Dactolisib Venetoclax 3 0
Dactolisib + WEHI-539 Dactolisib WEHI-539 5 0


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